On the mechanism of stereoselection in direct Mannich reaction catalyzed by BINOL-derived phosphoric acids
Tetrahedron LettersPublished 2 December 2006
Ilya D. Gridnev, Mitsuhiro Kouchi, Keiichi Sorimachi, Masahiro Terada
Citations78
SJR quartileQ3
SJR score0.33
SNIP0.43
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Abstract
Associates between the chiral phosphoric acids and Boc-protected imine were characterized computationally and by NMR; the primary importance of the bulky protecting group in imine for the high enantioselectivity in the direct Mannich reaction is rationalized via the analysis of the stereodiscriminating intermediates.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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