Interacting Effects of the Dopamine Transporter Gene and Psychosocial Adversity on Attention-Deficit/Hyperactivity Disorder Symptoms Among 15-Year-Olds From a High-Risk Community Sample
Archives of General PsychiatryPublished 1 May 2007
Manfred Laucht, Markus H. Skowronek, Katja Becker, Martin H. Schmidt, Günter Esser, Thomas G. Schulze
Citations204
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Findings provide initial evidence that environmental risks as described by the Rutter Family Adversity Index moderate the impact of the DAT1 gene on ADHD symptoms, suggesting a Dat1 effect only in those individuals exposed to psychosocial adversity.
Abstract
These findings provide initial evidence that environmental risks as described by the Rutter Family Adversity Index moderate the impact of the DAT1 gene on ADHD symptoms, suggesting a DAT1 effect only in those individuals exposed to psychosocial adversity.
Keywords
PsychologyMedicine
The American Journal of Human GeneticsA New Statistical Method for Haplotype Reconstruction from Population Data
7,548 Citations2001Matthew Stephens, Nicholas Smith +1 more
A new statistical method is presented, applicable to genotype data at linked loci from a population sample, that improves substantially on current algorithms and performs well in absolute terms, suggesting that reconstructing haplotypes experimentally or by genotyping additional family members may be an inefficient use of resources.
Psychological ReviewBiobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.
3,279 Citations2000Shelley E. Taylor, Laura Cousino Klein +4 more
It is proposed that, behaviorally, females' responses to stress are more marked by a pattern of "tend-and-befriend," and neuroendocrine evidence from animal and human studies suggests that oxytocin, in conjunction with female reproductive hormones and endogenous opioid peptide mechanisms, may be at its core.
NatureHyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
2,481 Citations1996Bruno Giros, Mohamed Jaber +3 more
In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission.
Biological PsychiatryMolecular Genetics of Attention-Deficit/Hyperactivity Disorder
2,366 Citations2005Stephen V. Faraone, Roy H. Perlis +5 more
Family, twin, and adoption studies provide compelling evidence that genes play a strong role in mediating susceptibility to ADHD, and seven genes for which the same variant has been studied in three or more case-control or family-based studies show statistically significant evidence of association with ADHD.
Genetic EpidemiologyPedigree disequilibrium tests for multilocus haplotypes
1,137 Citations2003Frank Dudbridge
A permutation procedure for the null hypothesis of interest is described, which controls for violation of the assumptions, and a likelihood‐ratio test is proposed, using the expectation‐maximization (E‐M) algorithm to account for haplotype ambiguities.
Annual Review of NeuroscienceNeurotransmitter Transporters: Recent Progress
1,088 Citations1993Susan Amara, Michael J. Kuhar
ScienceThe Genetic Basis of Complex Human Behaviors
1,028 Citations1994Robert Plomin, Michael J. Owen +1 more
This work states that quantitative genetic research has built a strong case for the importance of genetic factors in many complex behavioral disorders and dimensions in the domains of psychopathology, personality, and cognitive abilities.
PubMedAssociation of attention-deficit disorder and the dopamine transporter gene.
1,005 Citations1995Edwin H. Cook, Mark A. Stein +5 more
Archives of General PsychiatryStrategy for Investigating Interactions Between Measured Genes and Measured Environments
782 Citations2005Terrie E. Moffitt, Avshalom Caspi +1 more
It is suggested that in psychiatric genetics, ignoring nurture handicaps the field's capacity to make new discoveries about nature and the potential benefits of the measured-GxE approach for basic neuroscience and for gene hunting are explained.
Journal of the American Academy of Child & Adolescent PsychiatryHistorical Development and Present Status of the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS)
724 Citations2000Paul J. Ambrosini
The K-SADS is a viable interview schedule to assess current, past, and lifetime diagnostic status in children and adolescents and has the potential to further aide in the validation of psychiatric disorders.
GenomicsHuman dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR
709 Citations1992David J. Vandenbergh, Antonio M. Persico +5 more
Analysis of a 40-bp repeat in the 3' untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies, which will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.
The LancetDopamine transporter density in patients with attention deficit hyperactivity disorder
685 Citations1999Darin D. Dougherty, Ali A. Bonab +4 more
Dopamine transporter density was measured in vivo in six adult patients with attention deficit hyperactivity disorder and showed a 70% increase in age-corrected dopamine transporter density.
NeuropsychopharmacologyGenotype Influences In Vivo Dopamine Transporter Availability in Human Striatum
538 Citations2000Andreas Heinz
It is suggested that the VNTR polymorphism of the DAT gene effects translation of theDAT protein, which may explain a variety of clinical associations that have been reported with this polymorphism.
Archives of General PsychiatryFamily-Environment Risk Factors for Attention-Deficit Hyperactivity Disorder
480 Citations1995Joseph Biederman
A positive association appears to exist between adversity indicators and the risk for ADHD as well as for its associated psychiatric, cognitive, and psychosocial impairments.
Annual Review of PsychologyGene-Environment Interplay in Relation to Emotional and Behavioral Disturbance
461 Citations2002Michael Rutter, Judy L. Silberg
Archives of General PsychiatryA Common Haplotype of the Dopamine Transporter Gene Associated With Attention-Deficit/Hyperactivity Disorder and Interacting With Maternal Use of Alcohol During Pregnancy
322 Citations2006Keeley J. Brookes, Jonathan Mill +11 more
A novel association was identified between ADHD, the intron 8 polymorphism, and a specific risk haplotype in both English and Taiwanese samples, and interaction between DAT1 genotypes and maternal use of alcohol during pregnancy suggests that Dat1 moderates the environmental risk and has implications for the prevention of ADHD.
Child and Adolescent Psychiatric Clinics of North AmericaThe Nature and Heritability of Attention-Deficit/Hyperactivity Disorder
303 Citations2001Stephen V. Faraone, Alysa E. Doyle
It is suggested that both genetic and environmental factors contribute to the etiology of ADHD, and data do implicate dysfunction in the frontosubcortical pathways that control attention and motor behavior.
American Journal of PsychiatryDifferential Effect of Environmental Adversity by Gender: Rutter’s Index of Adversity in a Group of Boys and Girls With and Without ADHD
290 Citations2002Joseph Biederman, Stephen V. Faraone +1 more
Greater levels of environmental adversity were associated with a greater risk for ADHD and other comorbidity in both genders in a dose-dependent fashion, but gender modified the risk for adverse cognitive and interpersonal outcomes; boys were more vulnerable to the disorder than girls.
The Journal of PediatricsRole of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors
283 Citations2003Robert S. Kahn, Jane Khoury +2 more
Child hyperactivity-impulsivity and oppositional behaviors were associated with a DAT polymorphism but only when the child also had exposure to maternal prenatal smoking, emphasizing the importance of incorporating environmental cofactors in genetic studies of attention deficit hyperactivity disorder.
American Journal of PsychiatryPrediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report
275 Citations2000Leslie K. Jacobsen, Julie K. Staley +5 more
It is suggested that genetic variation at the SLC6A3 3' VNTR polymorphism may modify dopamine transporter function.
Journal of Child Psychology and PsychiatryDevelopmental Outcome of Infants Born with Biological and Psychosocial Risks
270 Citations1997Manfred Laucht, Günter Esser +1 more
Whereas psychosocial risks became more prominent with growing age and were related to poorer child outcome in all areas of functioning, biological risks decreased in influence and predominantly resulted in poorer motor development.
Journal of the American Academy of Child & Adolescent PsychiatryBehavioral Sequelae of Perinatal Insults and Early Family Adversity at 8 Years of Age
201 Citations2000Manfred Laucht, Günter Esser +9 more
The adverse impact of family adversity clearly outweighed the influence of obstetric complications in determining behavioral adjustment at school age.
NeuropsychopharmacologyThe Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans
184 Citations2001Diana Martinez
No significant association was found between VNTR polymorphism and amphetamine-induced dopamine release or DAT density in the total sample, nor when each diagnostic group was considered separately, which had suggested that the 9 repeat allele was associated with either an increased or decreased DAT expression, albeit in different patient populations.
Biological PsychiatryGlobal variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3)
181 Citations1999An-Jing Kang, Meg A. Palmatier +1 more
The large variation in allele frequencies observed in this study emphasizes the inadequacy of most past studies using the case-control design and the importance of matching patient and control populations in future association studies.
Biological PsychiatryHaplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
167 Citations2001Cathy L. Barr, Chun Xu +15 more
The results support previous findings of an association between the DAT1 gene and ADHD and investigate the possibility of linkage of Dat1 and ADHD using the VNTR polymorphism and two additional common polymorphisms in 102 nuclear families with an ADHD proband.
Molecular PsychiatryAssociation study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples
161 Citations2001Sarah Curran, Jonathan Mill +14 more
Analysis of the same VNTR marker in a dataset of UK Caucasian children and an independent dataset of Turkish Caucasian children with DSM-IV ADHD supports association and linkage between genetic variation at the DAT1 locus and ADHD.
Human GeneticsA 40-nucleotide repeat polymorphism in the human dopamine transporter gene
140 Citations1993Akira Sano, Keiji Kondoh +2 more
Molecular PsychiatryHuman dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations
133 Citations2000David J. Vandenbergh, Miles D. Thompson +11 more
It is suggested that gene variants that alter levels of DAT expression provide the best current candidate mechanism for reported associations between DAT gene markers, ADHD and other more tentatively associated neuropsychiatric disorders.
Psychiatric GeneticsMeta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder
95 Citations2005Diane Purper‐Ouakil, M. Wohl +4 more
The meta-analysis showed no significant association between ADHD and the DAT gene, but an important between-samples heterogeneity, and the different biases detected herein probably explain the initial impression of a significant impact of the Dat gene on hyperactivity.
American Journal of Medical Genetics Part B Neuropsychiatric GeneticsSequence variation in the 3′‐untranslated region of the dopamine transporter gene and attention‐deficit hyperactivity disorder (ADHD)
51 Citations2005Yu Feng, Karen Wigg +9 more
This study investigated whether DNA variation in the DAT1 3′UTR contributed to ADHD by genotyping DNA variants around the VNTR region in a sample of 178 ADHD families, and indicated that Dat1 is associated with ADHD in this sample but not with alleles of the VnTR polymorphism.
