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The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆II. Inhibition: Nomenclature and theory

Biochimica et Biophysica ActaPublished 1 January 1963
W. W. Cleland
Citations867

TL;DR

A nomenclature is proposed to describe different types of inhibitions of enzyme-catalyzed reactions, particularly for reactions with more than one substrate and product, and the rate equations for such inhibitions are discussed.

Abstract

A nomenclature is proposed to describe different types of inhibitions of enzyme-catalyzed reactions, particularly for reactions with more than one substrate and product. The rate equations for such inhibitions are discussed, as are methods for distinguishing between the various types of inhibition and obtaining inhibition and kinetic constants from experimental data. Several examples are given of the type of information that can be obtained from inhibition studies.

Keywords

ChemistryBiochemistry, Genetics and Molecular Biology