A renaissance for SRC
Nature reviews. CancerPublished 1 June 2004
Timothy J. Yeatman
Citations1,085
SJR quartileQ1
SJR score24.38
SNIP11.13
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TL;DR
A key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression.
Abstract
The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. These observations have led to the recent targeting of c-SRC for the development of anticancer therapeutics, which show promise as a new avenue for cancer treatment. Despite this, however, the precise functions of c-SRC in cancer remain unclear. In addition to increasing cell proliferation, a key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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12 revertants of a clonal line of avian sarcoma virus-transformed rat-1 cells are isolated and characterized, finding that they arise as a consequence of nonconditional mutations in the viral transforming gene, src.
Experimental Cell ResearchInactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeleton
71 Citations2003Witold W. Kilarski, Natalia Jura +1 more
Journal of Biological ChemistryActivated Src Oncogene Phosphorylates R-Ras and Suppresses Integrin Activity
65 Citations2002June X. Zou, Yanqiu Liu +2 more
It is shown that Src regulates cell adhesion through R-Ras and integrins, and that activation of an activated form of Src similar to one that has been found in human cancers, Src527, shared with v-Src the ability to phosphorylate R- Ras.
OncogeneCbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation
64 Citations2003Minsoo Kim, Tohru Tezuka +2 more
The results suggest that Cbl and Cbl-b suppress v-Src-induced transformation through mechanisms distinct from that of C Bl-c, and activated Src may be a direct target of CBl-c in vivo.
Experimental Cell ResearchMultiple Roles for Src in a PDGF-Stimulated Cell
60 Citations1999Kris A. DeMali, Stephen L. Godwin +2 more
Src is a versatile signal relay enzyme, whose contribution to a signaling cascade depends on variables such as the nature of the receptor via which the cell is activated, as well as the cell type itself.
International Journal of CancerOverexpression of thecsk gene suppresses tumor metastasisin vivo
58 Citations2000Takumi Nakagawa, Sakae Tanaka +5 more
It is reported herein that down‐regulation of Src kinase activity by adenovirus‐mediated csk gene transfer abrogated the highly metastatic phenotype of colon cancer cells.
PubMedElevated c-Src protein expression is an early event in colonic neoplasia.
57 Citations1998Siavash Iravani, Weiguang Mao +5 more
Elevated c-Src expression is an important early event during colorectal carcinogenesis; its activation may be involved in tumor progression in a subset of colonic carcinomas; and additional molecular events are necessary for invasion to occur.
Journal of Clinical InvestigationDifferential pp60c-src activity in well and poorly differentiated human colon carcinomas and cell lines.
55 Citations1992Thomas K. Weber, G Steele +1 more
Using an antiphosphotyrosine antibody in immunoprecipitation revealed the presence of novel phosphotyrosyl cellular substrates in human colon cell lines displaying elevated pp60c-src kinase activity, suggesting a role for the src protooncogene in colonic differentiation pathways.
Journal of Biological Chemistryv-Src Rescues Actin-based Cytoskeletal Architecture and Cell Motility and Induces Enhanced Anchorage Independence during Oncogenic Transformation of Focal Adhesion Kinase-null Fibroblasts
49 Citations2003Konstadinos Moissoglu, Irwin H. Gelman
FAK, although dispensable, attenuates v-Src-induced oncogenic transformation by modulating distinct signaling and cytoskeletal pathways, suggesting that FAK attenuates Srcinduced anchorage independence.
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