Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder
American Journal of PsychiatryPublished 1 July 2000
J. Douglas Bremner, Robert B. Innis, Steven M. Southwick, Lawrence H. Staib, Sami S. Zoghbi, Dennis S. Charney
Citations451
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
Lower distribution volumes were found in the prefrontal cortex of PTSD patients than in comparison subjects, consistent with fewer benzodiazepine receptors and/or reduced affinity of receptor binding in the medial prefrontal cortex in patients with PTSD.
Abstract
These findings of lower values for the benzodiazepine receptor binding measure of distribution volume are consistent with fewer benzodiazepine receptors and/or reduced affinity of receptor binding in the medial prefrontal cortex in patients with PTSD. Alterations in benzodiazepine receptor function in this area may underlie many of the symptoms of PTSD.
Keywords
Neuroscience
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