Electrical and mechanical responses from ventricular muscle fibers after inactivation of the sodium carrying system
Pflügers Archiv - European Journal of PhysiologyPublished 1 January 1970
Dieter Mascher
Citations107
SJR quartileQ1
SJR score1.06
SNIP0.92
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The electrical and mechanical responses of spontaneously and KCl depolarized ventricular fibers (cat and dog) were studied using a modified sucrose gap technique.
Abstract
The electrical and mechanical responses of spontaneously and KCl depolarized ventricular fibers (cat and dog) were studied using a modified sucrose gap technique. The following observations were made:
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
The Journal of PhysiologyA quantitative description of membrane current and its application to conduction and excitation in nerve
23,234 Citations1952A. L. Hodgkin, A. F. Huxley
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.
The Journal of PhysiologyThe dual effect of membrane potential on sodium conductance in the giant axon of <i>Loligo</i>
1,589 Citations1952A. L. Hodgkin, A. F. Huxley
This paper contains a further account of the electrical properties of the giant axon of Loligo and deals with the 'inactivation' process which gradually reduces sodium permeability after it has undergone the initial rise associated with depolarization.
Annals of Internal MedicineElectrophysiology of the Heart.
1,320 Citations1960
The graphic registration which forms the basis for many illustrations is of less than optimal quality, and many useful techniques, such as left heart catheterization, the analysis of the central arterial pulse, direct oximetry, and differential dye analysis, are entirely omitted.
The Journal of PhysiologyThe effect of the cardiac membrane potential on the rapid availability of the sodium‐carrying system
761 Citations1955Silvio Weidmann
The present experiments were undertaken in order to look for a similar effect in mammalian Purkinje fibres by means of a feedback circuit the 'resting' potential could be chosen at will; its effect was observed on certain features of the action potential which are thought to be indicative of the sodium permeability, namely the upstroke velocity and the size of the 'overshoot'.
Pflügers Archiv - European Journal of PhysiologyExistence and role of a slow inward current during the frog atrial action potential
447 Citations1969O Rougier, Guy Vassort +2 more
The pathway for slow current for frog atrial heart muscle fibers is proposed to be called “slow channel”, thinking that it is probably at this level that the competition between sodium and calcium occurs and plays an important role during the plateau and the repolarization of the action potential.
The Journal of General PhysiologyDifferences in Na and Ca Spikes As Examined by Application of Tetrodotoxin, Procaine, and Manganese Ions
426 Citations1966Susumu Hagiwara, Shigehiro Nakajima
Circulation ResearchInotropic Effects of Electric Currents
306 Citations1969Earl H. Wood, Richard L. Heppner +1 more
Tension was recorded from a segment of a thin bundle of calf or sheep ventricular fibers in which the membrane potential could be changed electrically, using a sucrose-gap technique and positive inotropic effects obtained were consistent with two hypotheses.
Cellular and Molecular Life SciencesA new method for measuring membrane potentials with external electrodes
270 Citations1954R. Stämpfli
The Journal of PhysiologyThe dual effect of calcium on the action potential of the frog's heart
207 Citations1966R. Niedergerke, Richard K. Orkand
Using ventricle strips of the frog's heart stimulated at the low rate of about 1 shock/min intracellular action potentials were recorded under conditions of varying calcium concentrations.
ScienceCalcium Current and Activation of Contraction in Ventricular Myocardial Fibers
159 Citations1969H. Réuter, George W. Beeler
In thin bundles of dog ventricular myocardium, a slow inward current could be recorded under voltageclamp conditions and this inward current was influenced by changes in external calcium concentration, but it was not dependent on external sodium concentration.
The Journal of General PhysiologyTwo Components of the Cardiac Action Potential
152 Citations1969Antonio Paes de Carvalho, Brian F. Hoffman +1 more
Results showed that differences in time course of action potential upstroke can be explained in terms of the relative magnitude of fast and slow phases of depolarization, and acetylcholine is capable of depressing the slow phase ofdepolarization as well as the plateau of the action potential.
Pflügers Archiv - European Journal of PhysiologyTwo components of inward current in myocardial muscle fibers
134 Citations1969Dieter Mascher, K. Peper
The membrane potential of trabecula of the sheep ventricle was clamped and a transient inward current lasting 100 ms was elicited, which was concluded that this component is carried by sodium ions.
Pflügers Archiv - European Journal of Physiology�ber den Einflu� der extracellul�ren Ca-Konzentration auf Membranpotential und Kontraktion isolierter Herzpr�parate bei graduierter Depolarisation
95 Citations1968H. Réuter, Hasso Scholz
Pflügers Archiv - European Journal of PhysiologyNachweis von zwei Komponenten in der Anstiegsphase des Aktionspotentials von Froschmyokardfasern
47 Citations1965H. Antoni, W. Delius
American Journal of Physiology-Legacy ContentAction potential of amphibian single auricular muscle fiber: a dual response
41 Citations1961Ernest B. Wright, Masahiko Ogata