Melatonin and adjustment to phase shift
Journal of Sleep ResearchPublished 1 December 1995Open access
Joséphine Arendt, Steven Deacon, Judie English, Shelagh M. Hampton, Linda Morgan
Citations92
SJR quartileQ1
SJR score1.52
SNIP1.44
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TL;DR
Melatonin has clear circadian phase‐shifting effects in humans which have recently been formalized as a phase response curve and its potential use in circadian rhythm disorders has been investigated in field studies of jet lag and shift work and in simulated phase shift.
Abstract
The pineal hormone melatonin has clear circadian phase-shifting effects in humans which have recently been formalized as a phase response curve. Its potential use in circadian rhythm disorders has been investigated in field studies of jet lag and shift work and in simulated phase shift. A substantial amount of information indicates that in the majority of subjects it hastens adaptation of both subjective and objective measures to forced shifts in time cues with few reported side-effects. Field studies of its use in adaptation to shift work are sparse and preliminary but the first indications are positive. In some blind subjects with sleep disturbance it can stabilize sleep onset time without necessarily entraining all circadian rhythms and it can advance sleep timing in delayed sleep-phase insomnia. Acute suppression of core body temperature may be an integral part of the phase-shifting mechanism.
Keywords
PsychologyNeuroscience
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