Ordered Recruitment
Molecular CellPublished 1 August 2002Open access
Maria Pia Cosma
Citations261
SJR quartileQ1
SJR score9.05
SNIP2.89
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TL;DR
The timing of the activation of transcription and the ordered recruitment of factors to promoters are the engines which, at the right moment and for the right length of time, drive the transcriptional regulation of each gene throughout the life of a cell.
Abstract
Activators, chromatin-modifying enzymes, and basal transcription factors unite to activate genes, but are recruited in a precise order to promoters. The timing of the activation of transcription and the ordered recruitment of factors to promoters are the engines which, at the right moment and for the right length of time, drive the transcriptional regulation of each gene throughout the life of a cell.
Keywords
Biochemistry, Genetics and Molecular Biology
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