Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone
Life SciencesPublished 1 August 1977
J.F. Bruni, D. Van Vugt, Sarah Marshall, J. Meites
Citations579
SJR quartileQ1
SJR score1.31
SNIP1.07
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TL;DR
It is suggested that endogenous morphinomimetic substances may participate in regulating secretion of anterior pituitary hormones through regulating the response to naloxone and morphine.
Abstract
The response of 5 anterior pituitary hormones to single injections of naloxone, morphine and metenkephalin administration was measured in male rats. Morphine and met-enkephalin significantly increased serum prolactin and GH concentrations, and significantly decreased serum LH and TSH concentrations. Naloxone reduced serum prolactin and GH concentrations, increased serum LH and FSH, but had little effect on serum TSH concentrations. Concurrent injections of naloxone with morphine or met-enkephalin reduced the response to each of the drugs given separtely. These results suggest that endogenous morphinomimetic substances may participate in regulating secretion of anterior pituitary hormones.
Keywords
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