N‐Heterocyclic Carbene Catalyzed Homoenolate‐Addition Reaction of Enals and Nitroalkenes: Asymmetric Synthesis of 5‐Carbon‐Synthon δ‐Nitroesters
Angewandte Chemie International EditionPublished 23 July 2012
Biswajit Maji, Li Ji, Siming Wang, Seenuvasan Vedachalam, Rakesh Ganguly, Xue‐Wei Liu
Citations74
SJR quartileQ1
SJR score5.55
SNIP2.47
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Abstract
Synthesizing synthons: The highly enantioselective title reaction is described. It employs catalytic amounts of N-heterocyclic carbene precursors and transforms a broad range of nitroalkenes, such as nitrodienes, nitroenynes, and nitrostyrenes, through reaction with a broad range of enals, into δ-nitroesters via homoenolate intermediates (see scheme).
Keywords
Chemistry
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