Heroin reward is dependent on a dopaminergic substrate
Life SciencesPublished 1 November 1981
Michael A. Bozarth, Roy A. Wise
Citations334
SJR quartileQ1
SJR score1.31
SNIP1.07
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TL;DR
The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate, supporting the notion that opiates and other sources of reward activate a similar neural substrate.
Abstract
The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate. The involvement of a dopaminergic mechanism in this effect supports the notion that opiates and other sources of reward activate a similar neural substrate.
Keywords
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