Dopamine: Release from the Brain in vivo by Amantadine
SciencePublished 22 October 1971
P. F. VON VOIGTLANDER, Kenneth E. Moore
Citations139
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
After dopamine stores in the caudate nucleus of cats were labeled with [3H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid and the addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [ 3H]Dopamine appearing in the perfusion effluent.
Abstract
After dopamine stores in the caudate nucleus of cats were labeled with [(3)H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid. The addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [(3)H]dopamine appearing in the perfusion effluent. Subthreshold concentrations of amantadine also enhanced the efflux of [(3)H]dopamine induced by electrical stimulation of the caudate nucleus.
Keywords
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