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Potentiation of Cocaine-Induced Coronary Vasoconstriction by Beta-Adrenergic Blockade

Annals of Internal MedicinePublished 15 June 1990
Richard A. Lange, Ricardo G. Cigarroa, Eduardo D. Flores, Wade McBride, Anatole S. Kim, Peter J. Wells
Citations415
SJR quartileQ1
SJR score3.38
SNIP3.27

TL;DR

Beta-adrenergic blocking agents probably should be avoided in patients with cocaine-associated myocardial ischemia or infarction because they potentiate cocaine-induced coronary vasoconstriction, which is potentiated by beta- adrenergic blockade.

Abstract

Cocaine-induced coronary vasoconstriction is potentiated by beta-adrenergic blockade. Beta-adrenergic blocking agents probably should be avoided in patients with cocaine-associated myocardial ischemia or infarction.

Keywords

Medicine