Multiple unit activity during habituation, sleep-wakefulness cycle and the effect of ACTH and corticosteroid treatment
Physiology & BehaviorPublished 1 September 1971
L Korányi, Carlos Beyer, C Guzmán-Flores
Citations26
SJR quartileQ2
SJR score0.78
SNIP0.84
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TL;DR
The present data indicate that both ACTH and corticosteroids have a decreasing effect on the brain excitability and they suggest that through this mechanism they might influence the process of habituation.
Abstract
Experiments were carried out on chronically implanted freely moving cats. The multiple unit activity (MUA) of mesencephalic reticular formation, midline thalamic nuclei, medial forebrain bundle, medial preoptic area and fornix was studied during habituation to a novel environment and the effect of pituitary adrenocortical hormones on this process was tested. MUA was continuously recorded during attentive behavior, slow-wave sleep, paradoxical phase of sleep (PPS), and auditory and somatic stimulation. A gradual, though marked decrease was found in the MUA levels of all structures in the course of consecutive sessions. The animals were considered as habituated to the environment when the MUA levels for each type of activity remained at a constant value. Hormone injections (ACTH; hydrocortisone, cortisone and corticosterone) were given to non-habituated and habituated animals. All the above mentioned hormones induced marked decrease in MUA in all animals, ACTH and hydrocortisone reduced both the number and duration of PPS on the day of hormone administration, while corticosterone and cortisone resulted in an increase. The present data indicate that both ACTH and corticosteroids have a decreasing effect on the brain excitability and they suggest that through this mechanism they might influence the process of habituation.
Keywords
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