Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus
NaturePublished 1 February 1982
Barbara Levinson, George Khoury, George Vande Woude, Peter Gruß
Citations274
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
A 72-bp repeat derived from the long terminal repeat (LTR) of cloned Moloney murine sarcoma virus (MSV) DNA can substitute functionally for the SV40 repeats and generate a viable virus in monkey kidney cells.
Abstract
The simian virus 40 (SV40) 72-base pair (bp) tandem-repeated sequences have a crucial role as an activator element in viral gene expression. We replaced the SV40 72-bp repeat with a 72-bp repeat derived from the long terminal repeat (LTR) of cloned Moloney murine sarcoma virus (MSV) DNA. Although there is no detectable sequence homology to SV40, the MSV repeats can substitute functionally for the SV40 repeats and generate a viable virus in monkey kidney cells.
Keywords
Agricultural and Biological SciencesMedicineBiochemistry, Genetics and Molecular Biology
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