The size of the prize for earlier diagnosis of cancer in England
British Journal of CancerPublished 1 December 2009Open access
M A Richards
Citations225
SJR quartileQ1
SJR score3.14
SNIP1.83
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Between 5000 and 10000 deaths within 5 years of diagnosis could be avoided every year in England if efforts to promote earlier diagnosis and appropriate primary surgical treatment are successful.
Abstract
Between 5000 and 10000 deaths within 5 years of diagnosis could be avoided every year in England if efforts to promote earlier diagnosis and appropriate primary surgical treatment are successful. Detailed international benchmarking studies are to be recommended.
Keywords
Medicine
The LancetEffects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
7,563 Citations2005
The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
The LancetEffects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials
5,078 Citations2005Mike Clarke, Rory Collins +14 more
It is found that variations in local treatment that substantially affect the risk of locoregional recurrence could also affect long-term breast cancer mortality, and that avoidance of a local recurrence in the conserved breast is recommended.
CHEST JournalRevisions in the International System for Staging Lung Cancer
4,598 Citations1997Clifton F. Mountain
Analysis of a collected database representing all clinical, surgical-pathologic, and follow-up information for 5,319 patients treated for primary lung cancer confirmed the validity of the TNM and stage grouping classification schema.
RespirationHigh Performance of <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography and Contrast-Enhanced CT in a Rapid Outpatient Diagnostic Program for Patients with Suspected Lung Cancer
4,004 Citations2013Pepijn Brocken, Henricus F.M. van der Heijden +3 more
FDG-PET/CT in an RODP setting for suspected lung cancer has high performance in detecting cancer and facilitates timely care and analysis of timeliness and diagnostic performance to differentiate malignant from benign lesions.
The LancetRECURRENCE AND SURVIVAL AFTER TOTAL MESORECTAL EXCISION FOR RECTAL CANCER
2,718 Citations1986Richard J. Heald, R. D. H. Ryall
On this evidence, it is often safe to limit mural clearance and thus preserve the anal sphincters, provided that the mesorectum is excised intact with the cancer.
New England Journal of MedicineImproved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer
2,504 Citations1997Swedish Rectal Cancer Trial
A short-term regimen of high-dose preoperative radiotherapy reduces rates of local recurrence and improves survival among patients with resectable rectal cancer.
Colorectal DiseaseStandardized surgery for colonic cancer: complete mesocolic excision and central ligation – technical notes and outcome
1,645 Citations2008Werner Hohenberger, Klaus Weber +3 more
This technique is focused on an intact package of the tumour and its main lymphatic drainage and this technique is nowadays accepted worldwide for optimal rectal cancer surgery.
The LancetInfluence of delay on survival in patients with breast cancer: a systematic review
1,166 Citations1999MA Richards, AM Westcombe +3 more
Delays of 3-6 months are associated with lower survival and efforts should be made to keep delays by patients and providers to a minimum, and longer delays were associated with more advanced stage.
The LancetEfficacy of adjuvant fluorouracil and folinic acid in colon cancer
1,060 Citations1995
It is concluded that fluorouracil plus high-dose folinic acid is a well-tolerated and effective 6-month adjuvant regimen for colon cancer.
The LancetEffect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial
1,045 Citations2009Philip Quirke, R. Steele +11 more
In rectal cancer, the plane of surgery achieved is an important prognostic factor for local recurrence, and both a negative circumferential resection margin and a superior plane of Surgery achieved were associated with lowLocal recurrence rates.
Diseases of the Colon & RectumA National Strategic Change in Treatment Policy for Rectal Cancer—Implementation of Total Mesorectal Excision as Routine Treatment in Norway. A National Audit
565 Citations2002Arne Wibe, Bjørn Møller +7 more
A refinement of the surgical resection technique for rectal cancer can be achieved on a national level, the technique of total mesorectal excision can be widely distributed, and surgery alone can give good results.
JNCI Journal of the National Cancer InstituteRandomized Trial of Postoperative Adjuvant Chemotherapy With or Without Radiotherapy for Carcinoma of the Rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02
532 Citations2000Norman Wolmark
The addition of postoperative radiation therapy to chemotherapy in Dukes' B and C rectal cancer did not alter the subsequent incidence of distant disease, although there was a reduction in locoregional relapse when compared with chemotherapy alone.
The Lancet OncologyPathology grading of colon cancer surgical resection and its association with survival: a retrospective observational study
442 Citations2008Nicholas P. West, Eva Morris +4 more
There is marked variability in the plane of surgery achieved in colon cancer, which might be a new cost-effective method of decreasing morbidity and mortality in patients with colon cancer.
Journal of Clinical OncologyEfficacy of Adjuvant Fluorouracil and Folinic Acid in B2 Colon Cancer
442 Citations1999Erlichman, C, O'Connell, M +19 more
This data set does not support the routine use of FU + LV in all patients with B2 Colon cancer, and studies in B2 colon cancer designed with a no-treatment control arm should be considered appropriate.
International Journal of CancerStage at diagnosis is a key explanation of differences in breast cancer survival across Europe
311 Citations2003Milena Sant, Claudia Allemani +11 more
Overall 5‐year relative survival was highest in the French group of Bas‐Rhin, Côte d'Or, Hérault and Isère (86%), and lowest in Estonia (66%), and these geographic groups were characterised by the highest and lowest percentages of women with early stage disease.
GutUnderstanding variations in survival for colorectal cancer in Europe: a EUROCARE high resolution study
274 Citations2000Gemma Gatta, R Capocaccia +12 more
There was a twofold range in the risk of death from colorectal cancer even after adjustment for surgery and disease stage, and there were wide variations in diagnostic and surgical practices.
CancerTen-year survey of lung cancer treatment and survival in hospitals in the United States
263 Citations1999Willard A. Fry, Jerri Linn Phillips +1 more
This review focuses on primary lung cancer, which accounts for approximately 14% of all new cancers and 28% of cancer deaths in the U.S.
European Respiratory JournalResection rates and postoperative mortality in 7,899 patients with lung cancer
246 Citations1996RA Damhuis, P.R. Schütte
Age appears to be related to treatment choice and postoperative mortality in patients with lung cancer, however, even in patients over 70 yrs of age, resections can be performed at acceptable risk, implying that chronological age should not automatically determine treatment decisions.
Clinical OncologyThe contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies
223 Citations2004Graeme Morgan, Robyn L. Ward +1 more
It is clear that cytotoxic chemotherapy only makes a minor contribution to cancer survival in adults, and a rigorous evaluation of the cost-effectiveness and impact on quality of life is urgently required.
British journal of surgeryImpact of a surgical training programme on rectal cancer outcomes in Stockholm
197 Citations2004Anna Martling, T. Holm +5 more
The aim of this study was to evaluate the effects of an initiative to teach the TME technique on outcomes at 5 years after surgery.
British Journal of CancerCancer survival in England and the influence of early diagnosis: what can we learn from recent EUROCARE results?
168 Citations2009C S Thomson, D Forman
The 5∣1-year survival estimates remained significantly worse for lung, colorectal and prostate cancers, showing that although early detection could make some difference, late effects such as treatment and management of the patients were also influencing long-term outcome differences between England and Europe.
British Journal of CancerWhat if cancer survival in Britain were the same as in Europe: how many deaths are avoidable?
162 Citations2009Manar E. Abdel‐Rahman, Diane Stockton +3 more
Avoidable premature mortality among cancer patients diagnosed in Britain during 1985–1999 has represented 6–7% of cancer-related mortality compared with the mean survival in Europe, small but steady progress over the period 1985–2003.
ThoraxSymptoms and the early diagnosis of lung cancer
128 Citations2005SS Birring
Advances in the management of breast, cervical, and prostate cancer have led to improved survival rates, whereas mortality from lung cancer has remained largely unchanged.
Diseases of the Colon & RectumAdjuvant chemotherapy in colorectal carcinoma
91 Citations1997S. S. Dube, F. Heyen +1 more
Given the high incidence of colorectal carcinoma, the small benefit observed for those patients receiving chemotherapy is far from negligible, and indications for adjuvant chemotherapy warrant further discussion.
ThoraxLung cancer in Teesside (UK) and Varese (Italy): a comparison of management and survival
83 Citations2005Andrea Imperatori
Patients with lung cancer in Teesside presented at a later stage, with more aggressive types of tumour, and had higher co-morbidity than patients in Varese, and the resection rate was significantly lower and survival was worse.
British Journal of CancerA visual summary of the EUROCARE-4 results: a UK perspective
50 Citations2009Henrik Møller, Karen M. Linklater +1 more
The present superficial analysis does not exclude possible functions for other factors relating to the organisation and quality of cancer care services, including a less favourable stage distribution in the United Kingdom.
Lung CancerRegional differences in treatment and outcome in non-small cell lung cancer: A population-based study (Sweden)
45 Citations2008Gunnar Mýrdal, Kristina Lamberg +4 more
The likelihood of receiving treatment for NSCLC was highest at county centre A where both surgical treatment and chemotherapy were given more often and the risk of death was between 20% and 40% higher in the other counties after adjusting for age, stage, gender, time period, smoking status and histopathological type.
Annals of OncologyTreatment and survival in breast cancer in the Eastern Region of England
35 Citations2009Gordon Wishart, David Greenberg +4 more
Variation in treatment and survival may be attributed to lack of information, in particular nodal and ER status, thereby impacting on staging and prescription of adjuvant therapy.
