Detection of Mild Dementia in Community Surveys
Archives of NeurologyPublished 1 March 1997
Agneta Herlitz
Citations35
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The findings indicate the need of integration between clinical and cognitive data to increase the accuracy in detecting dementia in an early phase and suggest a combination of cognitive tests and clinical dementia diagnosis may miss a sizable proportion of prevalent dementia cases due to possible insensitivity to the same demographic variables.
Abstract
A combination of cognitive tests, especially tasks assessing episodic memory, can detect many subjects in a preclinical state of dementia who could be missed in the clinical diagnostic procedure due to subjects' relatively high age, low education, and female sex. However, cognitive tests also may miss a sizable proportion of prevalent dementia cases due to possible insensitivity to the same demographic variables. These findings indicate the need of integration between clinical and cognitive data to increase the accuracy in detecting dementia in an early phase.
Keywords
MedicineHealth Professions
Journal of Psychiatric Research“Mini-mental state”
86,858 Citations1975Marshal F. Folstein, Susan E. Folstein +1 more
A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
NeurologyIncidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population
828 Citations1995Tadamasa Yoshitake, Yutaka Kiyohara +11 more
It is suggested that asymptomatic stroke is an important factor in the development of VD, with age, prior stroke episodes, systolic blood pressure, and alcohol consumption being independent risk factors for its occurrence.
Archives of NeurologyDetection of Abnormal Memory Decline in Mild Cases of Alzheimer's Disease Using CERAD Neuropsychological Measures
731 Citations1991Katherine M. Welsh, Nelson Butters +3 more
It is suggested that tests for delayed recall may be particularly useful in the early detection of Alzheimer's disease and should be considered in screening batteries for dementia in community surveys.
NeurologyVery Old Women at Highest Risk of Dementia and Alzheimer's Disease
548 Citations1997Laura Fratiglioni, Matti Viitanen +4 more
The incidence of dementia increases with age, even in the oldest age groups, and women have a higher risk of developing dementia than men, especially at very old ages, mainly due to the age and gender distribution of Alzheimer's disease, rather than vascular dementia.
NeurologyPrevalence of Alzheimer's disease and other dementias in an elderly urban population
530 Citations1991Laura Fratiglioni, M. Grut +8 more
Alzheimer's disease (AD) was confirmed as the most frequent type of dementia and the positive association of dementias with age, even in the most advanced ages, and no sex differences regarding the prevalence of different dementia types were found.
Archives of NeurologyDetection and Staging of Dementia in Alzheimer's Disease
474 Citations1992Kathleen A. Welsh
Impairment of delayed recall was again found to be the best discriminator for detecting mild cases of Alzheimer's disease and a combination of measures including fluency, praxis, and recognition memory best differentiated cases with mild dementia from those with either moderate or severe stages of disease.
Annals of NeurologyDevelopment of dementing illnesses in an 80‐year‐old volunteer cohort
452 Citations1989Robert Katzman, M. Aronson +8 more
It is possible to identify a large cohort of 80‐year‐olds who are at low risk for AD and a smaller cohort at very high risk, prospectively followed over a 5‐year period.
NeurologyThe Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
438 Citations1993John C. Morris, S. D. Edland +7 more
It is found that rate-of-change determinations are less reliable when the observation period is 1 year or less, dementia progression may be nonlinear when described by certain measures, and that simple change scores do not accurately characterize the rate of decline.
Archives of NeurologyThe 'Preclinical Phase' of Probable Alzheimer's Disease
434 Citations1995Richard T. Linn
Findings support previous contentions that a "preclinical phase" of detectable cognitive deficits can precede the clinical diagnosis of probable AD by many years, and support the hypothesis that problems with secondary verbal memory are among the first signs of AD.
Archives of NeurologyClinical-Neuropathological Correlations in Alzheimer's Disease and Related Dementias
404 Citations1994Douglas Galasko, L A Hansen +7 more
Clinicians accurately predicted AD pathological findings or their absence in most cases, but Attributing other degenerative dementias to AD, misdiagnosing patients with combined AD and Lewy bodies and misjudging the vascular contribution to dementia were the major areas of inaccuracy.
Archives of NeurologyPsychometric Differentiation of Mild Senile Dementia of the Alzheimer Type
325 Citations1984Martha Storandt, Jack Botwinick +3 more
A brief (ten-minute), easily administered battery of four psychological tests was developed to classify successfully 98% of patients with mild dementia of the Alzheimer's type and healthy older persons matched for age, sex, and social position.
NeurologyWomen, myocardial infarction, and dementia in the very old
258 Citations1990M. K. Aronson, Wee Lock Ooi +7 more
A new finding is that history of myocardial infarction (MI) is associated with dementia, such that women with a history of MI were 5 times more prone to dementia than those without a history, which was not true for men.
Archives of NeurologyVery Mild Senile Dementia of the Alzheimer Type
251 Citations1989Martha Storandt
Consideration of premorbid individual differences in psychological functions will probably be required if psychometric test performances are to be effective in detecting SDAT in the very mild stage.
Archives of NeurologyNeuropsychological Function in Alzheimer's Disease
238 Citations1988Julia C. Becker
A review of the results of this and other studies suggests that the language impairment in AD may be associated with two distinct neuropsychological abnormalities: a lexical/semantic impairment that is unrelated to onset or progression of symptoms, and a syntactic impairment that may beassociated with earlier onset and more rapid progression of dementia.
International Journal of EpidemiologyIncidence of Dementia and Alzheimer's Disease in Elderly Community Residents of South-Western France
234 Citations1994Luc Letenneur, Daniel Commenges +2 more
Incidence rates of dementia, Alzheimer's disease and vascular dementia in a community population of South-Western France did not level off with age and were not different between genders.
Archives of NeurologyVery Mild Senile Dementia of the Alzheimer Type
198 Citations1989Eugene H. Rubin
Results suggest that the CDR 0.5 stage likely represents the incipient clinical manifestation of Alzheimer's disease and that the majority of subjects with CDR 1.5 have "very mild senile dementia of the Alzheimer type."
Archives of NeurologyNeuropsychological Deficits in Vascular Dementia vs Alzheimer's Disease
173 Citations1994Andrew Kertesz
The Writing sub Test of the WAB, the Picture Arrangement subtest of the WAIS-R, and the Motor Performance sub test of the MDRS were the best discriminators of AD and VAD in the overall and severely affected populations.
Memory & CognitionRecognition memory across the adult life span: The role of prior knowledge
158 Citations1991Lars Bäckman
The results suggest that the ability to utilize rich semantic knowledge to improve episodic memory is preserved in very old age, although the aging process may be associated with deficits in the abilityto utilize prior knowledge to support memory when the underlying representation lacks semantic and contextual features.
Archives of NeurologyThe Prognosis in Alzheimer's Disease
152 Citations1990David A. Drachman
It is suggested that initial degree of severity ("how far") rather than variation in the rate of progression ("how fast") best predicts prognosis in the early to intermediate stages of Alzheimer's disease.
The British Journal of PsychiatryIncidence of Clinically Diagnosed Subtypes of Dementia in an Elderly Population
146 Citations1995Carol Brayne, C. Gill +6 more
The striking rise in incidence rates of dementia in the very old appear to be due to Alzheimer's disease, while rates for vascular dementia remain relatively constant, but trends are particularly marked for minimal dementia, but emphasise the importance of Alzheimer's Disease in the community as a cause of cognitive decline of all degrees.
Psychological MedicineThe problem of mild dementia
126 Citations1984A. S. Henderson, Felicia A. Huppert
The single common feature in mild dementia is the presence of mild cognitive impairment, presumed to be a decline from a formerly higher level of functioning, and although there are appreciable problems in method which first require to be overcome, mild dementia promises to beA rewarding area for epidemiological study.
The Journals of Gerontology Series AMuscle Protein Turnover: Methodological Issues and the Effect of Aging
117 Citations1995J. O. Holloszy, K. Sreekumaran Nair
CortexPredictors of Decline in Alzheimer's Disease
74 Citations1991François Boller, James T. Becker +4 more
The results of this study do not support age of onset as a predictor of the course of AD, but poor performance on language tests does predict a more rapid rate of decline in AD.
Archives of NeurologyPsychometric Differentiation of Dementia
68 Citations1987Mary C. Tierney
Assessment batteries utilizing additional procedures to supplement cognitive testing are indicated to more accurately discriminate among the dementias.
Archives of NeurologyPredictors of Survival in Clinically Diagnosed Alzheimer's Disease and Multi-Infarct Dementia
63 Citations1989Daniel B. Hier, Jonathan Warach +2 more
Since MID patients were younger at onset, MID patients had a lower life quotient than SDAT patients, and history of hypertension, elevated systolic blood pressure, lower scores on tests of Block Designs, and Logico-Grammatical Comprehension predicted shorter survival in SDAT.
The Journals of Gerontology Series AEpisodic Memory and Visuospatial Ability in Detecting and Staging Dementia in a Community-Based Sample of Very Old Adults
38 Citations1995Agneta Herlitz, Robert D. Hill +2 more
The results of this investigation indicate that cognitively supported measures assessing episodic memory may be particularly useful in the detection of dementia, whereas visuospatial measures are more effective in staging the disease.
Acta Neurologica ScandinavicaDetection and staging of early clinical dementia
35 Citations2009Ove Almkvist, Lars Bäckman
The results indicate that the pattern of dysfunction is similar for different levels of dementia, suggesting that similar cognitive functions may be involved in detection and staging of dementia.
Archives of NeurologyPsychometric Discrimination of Moderate Senile Dementia of the Alzheimer Type
18 Citations1992Robert D. Hill, Martha Storandt +1 more
It was noted that specific ability domains, namely, short-term recognition memory, visuospatial reasoning, and verbal ability, contributed to the discriminant function.
International Journal of Geriatric PsychiatryA critique of current criteria for early dementia in epidemiological studies
14 Citations1993P. W. Burvill
It is concluded that, at present, there are too many fundamental conceptual and methodological problems to be overcome before the authors can successfully undertake large‐scale community epidemiological studies of mild dementia.
Acta Neurologica ScandinavicaThe next generation of cholinesterase inhibitors
4 Citations2009Abdu Adem
Several THA analogues were synthesized in an effort to minimize side effects and it is possible that some of these analogues with more potent cholinergic effect than THA might be the next generation of cholinesterase inhibitors which can be useful in the treatment of Alzheimer's disease.