Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus
Neuroscience LettersPublished 1 February 1991
Masabumi Minami, Yasushi Kuraishi, Takashi Yamaguchi, Satoru Nakai, Yoshikatsu Hirai, Masamichi Satoh
Citations257
SJR quartileQ2
SJR score0.77
SNIP0.67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is demonstrated that the immobilization stress induces the expression of IL-1β mRNA solely in the hypothalamus and suggest that IL- 1β is involved in the response to stress there.
Abstract
Immobilization stress induced interleukin-1 beta (IL-1 beta) mRNA in the rat hypothalamus. IL-1 beta mRNA was induced at 30 min after the start of immobilization, reached a maximum at 60 min and then was still detected with a decreased level at 120 min. However, 240 min after the start of the immobilization, IL-1 beta mRNA became hardly detectable despite the continuance of immobilization. Distinct expression of IL-1 beta mRNA was not detected in any other brain region examined at 30 and 60 min after the start of immobilization. These results demonstrate that the immobilization stress induces the expression of IL-1 beta mRNA solely in the hypothalamus and suggest that IL-1 beta is involved in the response to stress there.
Keywords
Immunology and MicrobiologyNeuroscience
ScienceInterleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor
1,516 Citations1987Robert M. Sapolsky, Catherine Rivier +3 more
In this report, human IL-1 is shown to activate the adrenocortical axis at the level of the brain, stimulating the release of the controlling hormone corticotropin-releasing factor (CRF) from the hypothalamus.
ScienceCorticotropin-Releasing Factor-Producing Neurons in the Rat Activated by Interleukin-1
1,161 Citations1987F. Berkenbosch, Joep van Oers +3 more
ScienceInterleukin-1 Immunoreactive Innervation of the Human Hypothalamus
764 Citations1988Christopher D. Breder, Charles A. Dinarello +1 more
Results indicate that IL-1 may be an intrinsic neuromodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.
The Journal of ImmunologyCorticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.
654 Citations1982David S. Snyder, Emil R. Unanue
The doses of hydrocortisone and prednisolone that inhibited by 50% Ia expression in cultured macrophages ranged around 2 to 5 x 10(-8) M.
EndocrinologyAdrenal and Urinary Catecholamines in Rats During Adaptation to Repeated Immobilization Stress
514 Citations1970Richard Květňanský, L Mikulaj
Urinary excretion of epinephrine was greater in rats subjected to repeated immobilization than in unstressed or once-immobilized rats and urinary catecholamine levels were increased by one immobilization.
The Journal of ImmunologyVisualization and characterization of interleukin 1 receptors in brain.
455 Citations1987William L. Farrar, P L Kilian +3 more
The pattern of IL 1 receptor distribution indicates the presence of receptors on neuron cell bodies and the localization to numerous discrete brain areas other than those hypothalamic sites involved in temperature regulation, suggesting a broader role for IL 1 in brain functioning than previously recognized.
Brain ResearchImmunoreactive interleukin-1β localization in the rat forebrain
344 Citations1990Ronald M. Lechan, Roberto Toni +5 more
These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.
EndocrinologyAdrenocorticotropin Release Induced by Intracerebroventricular Injection of Recombinant Human Interleukin-1 in Rats: Possible Involvement of Prostaglandin*
222 Citations1988Goro Katsuura, Paul E. Gottschall +2 more
The findings strongly suggest that the brain is the primary site of action of IL-1 beta, and that IL- 1 beta transmits the message of the immune system to the brain and, possibly, CRF neurons.
Nucleic Acids ResearchGenomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene
202 Citations1986Burton D. Clark, K L Collins +3 more
It is hypothesized that the human prointerleukin 1 (proIL-1) beta gene may have arisen by a reverse transcriptase mediated duplication of the related alpha gene.
Biochemical and Biophysical Research CommunicationsIdentification of a high-affinity receptor for interleukin-1 beta in rat brain
161 Citations1988Goro Katsuura, Paul E. Gottschall +1 more
Findings indicate that IL-1 beta receptors are heterogeneously distributed in the central nervous system and thatIL-1 alpha does not bind with IL- 1 beta receptors in the brain.
Biochemical and Biophysical Research CommunicationsConvulsants induce interleukin-1β messenger RNA in rat brain
157 Citations1990Masabumi Minami, Yasushi Kuraishi +4 more
These results provide the first evidence that intensive neuronal excitation induces Interleukin-1β mRNA in particular regions of the brain.