Stress and murine sarcoma virus (Moloney)-induced tumors.
PubMedPublished 1 July 1972
Alfred A. Amkraut, George F. Solomon
Citations90
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TL;DR
Stable stress-responsive models have been established in murine (Moloney) virus sarcomas, which lend themselves to further study of intervening immunological mechanisms, and maximum tumor size was increased and reduced in females subjected to 3 days of electric shock stress following virus inoculation.
Abstract
Stable stress-responsive models have been established in murine (Moloney) virus sarcomas, which lend themselves to further study of intervening immunological mechanisms. Maximum tumor size was increased in sex-segregated male BALB/c mice at 6 and 9 months of age and in females subjected to 3 days of electric shock stress following virus inoculation. Reduction in maximum tumor size was found in females shocked for 3 days prior to virus inoculation. Similarly, females that spontaneously showed fighting behavior developed smaller tumors. Possible endocrine and immunological factors contributing to these varied stress effects are discussed.
Keywords
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