Activity-Dependent Regulation of Conductances in Model Neurons
SciencePublished 26 March 1993
Gwendal Le Masson, Eve Marder, L. F. Abbott
Citations343
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity, and model neurons with activity-dependent maximal conductance modify their conductances to maintain a given behavior when perturbed.
Abstract
Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.
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