Regulation of the β-globin locus
Current Opinion in Genetics & DevelopmentPublished 1 January 1993
Merlin Crossley, Stuart H. Orkin
Citations85
SJR quartileQ1
SJR score2.09
SNIP0.90
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TL;DR
Transcription of the human β-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region, and the crux of transcriptional activation is how the loci control region communicates with the gene-proximal regulatory elements.
Abstract
Transcription of the human beta-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region. Recent studies have provided new insights into how the individual genes of the cluster are regulated through development. The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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CellDevelopmental regulation of β-globin gene switching
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Analysis of the chromatin structure of the beta-globin LCR during early hematopoietic differentiation using nontransformed, multipotential, growth factor-dependent, murine hematopolietic progenitor cells indicates a significant role for selective gene repression in lineage specification.
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A microenvironment-directed, two-step model for GATA-1 expression in differentiating hematopoietic progenitors that involves (i) cycle-dependent initiation and (ii) lineage-dependent maintenance or suppression is suggested.
NatureA single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin
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Test whether the point mutation found in the Greek non-deletion HPFH2,3 (guanine to adenine at nucleotide position –117) is the cause of the raised γ-globin levels in the adult stage and is not just a linked polymorphism, it is shown that these changes correlate with the loss of binding of the transcription factor GATA1 to the ιglobin promoter, suggesting that it may act as a negative regulator of the γ
The EMBO JournalIdentification of a stage selector element in the human gamma‐globin gene promoter that fosters preferential interaction with the 5′ HS2 enhancer when in competition with the beta‐promoter.
141 Citations1992Stephen M. Jane, Paul A. Ney +3 more
A nuclear protein found in human erythroid‐specific enhancer within hypersensitivity site 2 (HS2) of the human beta‐globin locus control region is identified and partially purified, that binds the −53 to −35 sequence of the gamma‐promoter.
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