Identification of Catalysts in Combinatorial Libraries

Methods that allow not only simultaneous testing of but also read-out of catalytic activity with parallel libraries and one-bead-one-compound libraries are reviewed.

Abstract

Combinatorial methods allow for the generation of a large number of structurally similar yet unique compounds. For catalyst discovery using combinatorial libraries, the challenge lies in the development of screening methods that allow for the fast, reliable, and general identification of catalytically active library members. This article reviews methods that allow not only simultaneous testing of but also read-out of catalytic activity with parallel libraries and one-bead-one-compound libraries.