Effect of childhood physical abuse on cortisol stress response
PsychopharmacologyPublished 13 September 2010
Linda L. Carpenter, Thaddeus T. Shattuck, Audrey R. Tyrka, Thomas D. Geracioti, Lawrence H. Price
Citations306
SJR quartileQ1
SJR score1.16
SNIP0.97
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In a non-clinical sample of women with minimal or no current psychopathology, physical abuse is associated with a blunted cortisol response to a psychosocial stress task.
Abstract
In a non-clinical sample of women with minimal or no current psychopathology, physical abuse is associated with a blunted cortisol response to a psychosocial stress task.
Keywords
PsychologyNeuroscience
Journal of Health and Social BehaviorA Global Measure of Perceived Stress
32,415 Citations1983Sheldon Cohen, Tom Kamarck +1 more
The Perceived Stress Scale showed adequate reliability and, as predicted, was correlated with life-event scores, depressive and physical symptomatology, utilization of health services, social anxiety, and smoking-reduction maintenance and was a better predictor of the outcome in question than were life- event scores.
Manual for the State-Trait Anxiety Inventory
25,350 Citations1970Charles D. Spielberger, Richard L. Gorsuch +1 more
Child Abuse & NeglectDevelopment and validation of a brief screening version of the Childhood Trauma Questionnaire
6,317 Citations2003David P. Bernstein, Judith A. Stein +9 more
These findings support the viability of the CTQ-SF across diverse clinical and nonreferred populations and demonstrated good criterion-related validity in a subsample of adolescents on whom corroborative data were available.
Journal of Child Psychology and PsychiatryValidity of adult retrospective reports of adverse childhood experiences: review of the evidence
2,792 Citations2004Jochen Hardt, Michael Rutter
JAMAChildhood Abuse, Household Dysfunction, and the Risk of Attempted Suicide Throughout the Life Span
2,226 Citations2001Shanta R. Dube, Robert F. Anda +4 more
A powerful graded relationship exists between adverse childhood experiences and risk of attempted suicide throughout the life span, and alcoholism, depressed affect, and illicit drug use, which are strongly associated with such experiences, appear to partially mediate this relationship.
Psychological MedicineThe Inventory of Depressive Symptomatology (IDS): psychometric properties
2,192 Citations1996A. John Rush, Christina M. Gullion +3 more
Analysis of sensitivity to change in symptom severity in an open-label trial of fluoxetine showed that the IDs-C and IDS-SR were highly related to the 17-item Hamilton Rating Scale for Depression.
JAMAPituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood
1,956 Citations2000Christine Heim
The findings suggest that hypothalamic-pituitary-adrenal axis and autonomic nervous system hyperreactivity, presumably due to CRF hypersecretion, is a persistent consequence of childhood abuse that may contribute to the diathesis for adulthood psychopathological conditions.
Psychosomatic MedicineImpact of Gender, Menstrual Cycle Phase, and Oral Contraceptives on the Activity of the Hypothalamus-Pituitary-Adrenal Axis
1,910 Citations1999Clemens Kirschbaum, Brigitte M. Kudielka +3 more
Although men seem to have a stronger hypothalamic drive in response to stressful stimulation than women, differences in salivary-free cortisol levels, at least in part, may be explained by estradiol-induced changes in corticosteroid-binding protein levels.
Biological PsychologySex differences in HPA axis responses to stress: a review
1,577 Citations2004Brigitte M. Kudielka, Clemens Kirschbaum
American Journal of Public HealthChild sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey
1,201 Citations2001Beth E. Molnar, Stephen L. Buka +1 more
CSA, whether alone or in a larger adversity cluster, is associated with substantial increased risk of subsequent psychopathology, and this study examined the relationship between child sexual abuse and subsequent onset of psychiatric disorders.
PsychoneuroendocrinologyWhy do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge
931 Citations2008Brigitte M. Kudielka, Dirk H. Hellhammer +1 more
This overview demonstrates the role of age and gender, endogenous and exogenous sex steroid levels, pregnancy, lactation and breast-feeding, smoking, coffee and alcohol consumption as well as dietary energy supply in salivary cortisol responses to acute stress.
Hormones and BehaviorChild maltreatment and the developing HPA axis
724 Citations2006Amanda R. Tarullo, Megan R. Gunnar
The developing HPA axis is under strong social regulation in infancy and early childhood and is vulnerable to perturbation in the absence of sensitive, responsive caregiving, and post-institutionalized children may provide a model to separate early adverse care histories from current adversity.
Archives of General PsychiatryElevated Inflammation Levels in Depressed Adults With a History of Childhood Maltreatment
639 Citations2008Andrea Danese, Terrie E. Moffitt +4 more
Information about experiences of childhood maltreatment may help to identify depressed individuals with elevated inflammation levels and, thus, at greater risk of cardiovascular disease.
Educational and Psychological MeasurementCautionary Note on Reporting Eta-Squared Values from Multifactor ANOVA Designs
584 Citations2004Charles A. Pierce, Richard A. Block +1 more
Biological PsychiatryDecreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
555 Citations2007Linda L. Carpenter, John Carvalho +7 more
In adults without diagnosable psychopathology, childhood maltreatment is associated with diminished HPA axis response to a psychosocial stressor.
Depression and AnxietyThe role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: A multiple regression analysis
432 Citations2002Christine Heim, D. Jeffrey Newport +4 more
The findings suggest that a history of childhood abuse per se is related to increased neuroendocrine stress reactivity, which is further enhanced when additional trauma is experienced in adulthood.
Psychological MedicineChildhood adversities and adult depression: basic patterns of association in a US national survey
383 Citations1993Ronald C. Kessler, William Magee
The long-term relationships between various forms of childhood adversity and adult episodes of major depression are explored in a representative household survey of the United States adult (age 25+) population.
PsychoneuroendocrinologyDevelopmental traumatology: a contributory mechanism for alcohol and substance use disorders
368 Citations2002Michael D. De Bellis
Developmental traumatology studies in developmental traumatology may prove to be critical in the effort to attempt to link the neurobiology of maltreatment-related PTSD with the neuro biology of alcohol and substance use disorders and in developing early strategies for the prevention of adolescent and adult alcohol and substances use disorders.
PsychoneuroendocrinologyDiminished cortisol responses to psychosocial stress associated with lifetime adverse events
365 Citations2007Bernet M. Elzinga, Karin Roelofs +4 more
It is suggested that, at least in healthy young males, adverse childhood events are associated with changes in HPA-axis functioning, and a significant blunted cortisol response was found in individuals with a history of adverse events.
Biological PsychiatryChildhood Maltreatment and Telomere Shortening: Preliminary Support for an Effect of Early Stress on Cellular Aging
334 Citations2009Audrey R. Tyrka, Lawrence H. Price +4 more
The results extend previous reports linking shortened leukocyte telomere length and caregiver stress to more remote stressful experiences in childhood and suggest that childhood maltreatment could influence cellular aging.
Child Abuse & NeglectPrevalence and demographic correlates of childhood maltreatment in an adult community sample
329 Citations2004Christine D. Scher, David R. Forde +2 more
The most common forms of trauma for both men and women were physical abuse, physical neglect, and emotional abuse, all of which were highly likely to co-occur, and differential relationships with particular maltreatment types were observed.
European Journal of NeurosciencePolymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
315 Citations2008Marcus Ising, Anna‐Mareike Depping +8 more
This reaction pattern suggests that subjects carrying FKBP5 variants are at risk of displaying chronically elevated cortisol levels after repeated stress constituting a risk factor for stress‐related diseases.
Biological PsychiatryChildhood Parental Loss and Adult Hypothalamic-Pituitary-Adrenal Function
251 Citations2008Audrey R. Tyrka, Lauren M Wier +5 more
Findings in this study are consistent with the hypothesis that early parental loss induces enduring changes in neuroendocrine function and are moderated by levels of parental care.
Hormones and BehaviorPrenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults
248 Citations2008Sonja Entringer, Robert Kumsta +3 more
This study provides first evidence in humans of an association between prenatal psychosocial stress exposure and subsequent alterations in the regulation of the HPA axis.
Biological PsychiatryMajor Depression in Late Life Is Associated with Both Hypo- and Hypercortisolemia
199 Citations2007Marijke A. Bremmer, Dorly J. H. Deeg +4 more
In older people, the association between cortisol and major depression is U-shaped, suggesting both hypo- and hyperactivity of the hypothalamic-pituitary-adrenal axis might represent different depression subtypes.
Biological PsychiatrySex Specific Associations between Common Glucocorticoid Receptor Gene Variants and Hypothalamus-Pituitary-Adrenal Axis Responses to Psychosocial Stress
185 Citations2007Robert Kumsta, Sonja Entringer +4 more
Significant sex specific associations between GR gene polymorphisms and HPA axis responses to psychosocial stress as well as GC sensitivity support the relevance of GRGene polymorphisms in Hpa axis regulation.
PsychoneuroendocrinologyBDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions
182 Citations2008Idan Shalev, Elad Lerer +6 more
Examination of individual responses by Genotype and Sex to a standardized social stress paradigm indicates that a common, functionally significant polymorphism in the BDNF gene modulates HPA axis reactivity and regulation during the TSST differently in men and women.
Journal of Clinical PsychologyFactor structure of the Profile of Mood States (POMS): Two partial replications
181 Citations1984John C. Norcross, Edward Guadagnoli +1 more
The POMS appears to be an internally consistent, multidimensional instrument with a relatively stable factor structure, which is partially attributable to social desirability, to high scale intercorrelations, and to the inherent confluence of psychopathology.
European Journal of PharmacologyCorticosteroid receptor polymorphisms: Determinants of vulnerability and resilience
177 Citations2008Roel H. DeRijk, E. R. de Kloet
Evidence is provided that dysregulation of MR and GR are causative in the pathogenesis of depression and that these MR-and GR-gene variants are part of the genetic make up that determines individual stress-responsivity and coping style, affecting vulnerability to disease.
PsychoneuroendocrinologyChildhood trauma and diurnal cortisol disruption in fibromyalgia syndrome
162 Citations2005Inka Weissbecker, Anna H. L. Floyd +3 more
It is suggested that severe traumatic experiences in childhood may be a factor of adult neuroendocrine dysregulation among fibromyalgia sufferers and psychosocial intervention may be indicated as a component of treatment for fibromyromyalgia.
Eating BehaviorsWeight concerns in individuals with body dysmorphic disorder
162 Citations2006Jennifer Ellen Kittler, William Menard +1 more
Drug and Alcohol DependenceReactivity to laboratory stress provocation predicts relapse to cocaine
148 Citations2009Sudie E. Back, Karen J. Hartwell +9 more
The findings provide further evidence of the ability of laboratory paradigms to predict relapse and interventions aimed at normalizing stress response, as measured using laboratory Paradigms, may prove useful in relapse prevention.
PsychoneuroendocrinologySex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion
109 Citations2009Stefan Wüst, Robert Kumsta +5 more
Findings support the view that the 5-HTTLPR is associated with a major neuroendocrine stress system and it could be speculated that the sex-specific nature of this association contributes to the distinct gender differences in the vulnerability for depression.
PsychoneuroendocrinologyEffort-reward-imbalance and overcommitment are associated with hypothalamus–pituitary–adrenal (HPA) axis responses to acute psychosocial stress in healthy working schoolteachers
88 Citations2008Silja Bellingrath, Brigitte M. Kudielka
The notion of HPA axis hyporeactivity in highly overcommitted schoolteachers is supported, as higher stress levels were solely related to significantly stronger plasma cortisol increases after TSST exposure, but this effect became non-significant controlling for depressive symptomatology.
PsychoneuroendocrinologySex differences in hormonal responses to a social stressor in chronic major depression
85 Citations2009Kevin K. Chopra, Arun Ravindran +7 more
Males and females with CMDD exhibited unique differences in cortisol responses to the social challenge relative to controls, with females having greater overall secretion of cortisol whereas in males, C MDD subjects had a blunted peak response to thesocial stressor.
Brain Behavior and ImmunityDeterminants of the NF-κB response to acute psychosocial stress in humans
83 Citations2008Jutta M. Wolf, Nicolas Rohleder +3 more
The present study shows for the first time in human psychosocial stress the negative association of cortisol and NF-kappaB, a major inducer of inflammatory genes, parallels results from in vitro studies.
International Journal of PsychophysiologySalivary cortisol and DHEA reactivity to psychosocial stress in socially anxious males
83 Citations2008Kentaro Shirotsuki, Shuhei Izawa +6 more
The results suggest that there may be reduced HPA axis reactivity to psychosocial stress in socially anxious people.
The Journal of Clinical Endocrinology & MetabolismBody Size at Birth Predicts Hypothalamic-Pituitary-Adrenal Axis Response to Psychosocial Stress at Age 60 to 70 Years
82 Citations2007Eero Kajantie, Kimmo Feldt +8 more
The hypothesis that both hyper- and hypocortisolism may be programmed during the fetal period is supported, with an inverse U-shaped relationship between birth weight and cortisol concentrations during psychosocial stress.
PsychoneuroendocrinologyEducation modulates cortisol reactivity to the Trier Social Stress Test in middle-aged adults
76 Citations2007Alexandra Fiocco, Ridha Joober +1 more
It is suggested that middle-aged individuals with a lower level of education may find the Trier Social Stress Test more stressful due to lower verbal capacity, which may lead to an increased cortisol response to the TSST when compared to Individuals with a higher level ofeducation.
PsychoneuroendocrinologyChildhood parental divorce and cortisol in young adulthood: Evidence for mediation by family income
58 Citations2009Amy Kraft, Linda J. Luecken
It is suggested that childhood parental divorce is associated with attenuated cortisol in young adulthood, which may be explained by lower income in divorced families.
Comprehensive PsychiatryChildhood trauma and basal cortisol in people with personality disorders
54 Citations2008Janine D. Flory, Rachel Yehuda +4 more
Examination of the influence of various forms of childhood abuse on basal cortisol levels in a sample of adults with Axis II personality disorders suggests that different forms of trauma may have distinct biological effects.
European Addiction ResearchImpact of Childhood Trauma on Hypothalamus-Pituitary-Adrenal Axis Activity in Alcohol-Dependent Patients
42 Citations2010Ingo Schäfer, Lisa Teske +6 more
It is suggested that childhood trauma is related to blunted ACTH and increased cortisol during withdrawal in alcohol-dependent patients and early life stress might be a confounding variable in studies of HPA function in alcohol dependence.
PsychoneuroendocrinologyRecent depressive and anxious symptoms predict cortisol responses to stress in men
36 Citations2009Kathryn P. Brooks, Theodore F. Robles
It is demonstrated that the recent experience of depressive and anxious symptoms is associated with smaller cortisol responses to a psychosocial stressor in a non-clinical population.
PsychoneuroendocrinologySalivary cortisol response to acute stress and its relation to psychological factors in women with chronic trapezius myalgia—A pilot study
27 Citations2009Anna Sjörs, Britt Larsson +4 more
A relatively favorable sample of female chronic trapezius myalgia patients exhibited normal circadian rhythm and normal salivary cortisol response magnitudes after a psychosocial stress test, and in the subgroup of responders, the MYA group showed indications of a slower salivARY cortisol response to psychossocial stress.
Journal of Psychiatric ResearchUrinary free cortisol and childhood trauma in cocaine dependent adults
24 Citations2002Alec Roy
Cross sectional data suggest the possibility that childhood trauma may have an effect on HPA axis function and thus predispose to psychiatric disorders in middle-aged cocaine dependent patients.