Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion
PsychoneuroendocrinologyPublished 27 February 2009
Stefan Wüst, Robert Kumsta, Jens Treutlein, Josef Frank, Sonja Entringer, Thomas G. Schulze
Citations109
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TL;DR
Findings support the view that the 5-HTTLPR is associated with a major neuroendocrine stress system and it could be speculated that the sex-specific nature of this association contributes to the distinct gender differences in the vulnerability for depression.
Abstract
These findings support the view that the 5-HTTLPR is associated with a major neuroendocrine stress system. It could be speculated that the sex-specific nature of this association contributes to the distinct gender differences in the vulnerability for depression.
Keywords
PsychologyMedicineNeuroscience
Nucleic Acids ResearchA simple salting out procedure for extracting DNA from human nucleated cells
20,585 Citations1988S.A. Miller, Dale D. Dykes +1 more
A rapid, safe and inexpensive method was developed to simplify the deprotein-ization procedure that yielded quantities comparable to those obtained from phenol-chloroform extractions, rendering the entire process of RFLP analysis free of toxic materials.
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8,130 Citations2003Avshalom Caspi, Karen Sugden +9 more
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6,148 Citations2004Ian C.G. Weaver, Nadia Cervoni +7 more
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The results suggest that gender, genetics and nicotine consumption can influence the individual's stress responsiveness to psychological stress while personality traits showed no correlation with cortisol responses to TSST stimulation.
Psychological BulletinAcute Stressors and Cortisol Responses: A Theoretical Integration and Synthesis of Laboratory Research.
5,808 Citations2004Sally S. Dickerson, Margaret E. Kemeny
Motivated performance tasks elicited cortisol responses if they were uncontrollable or characterized by social-evaluative threat (task performance could be negatively judged by others), when methodological factors and other stressor characteristics were controlled for.
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5,592 Citations2003Irving I. Gottesman, Todd D. Gould
The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics.
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4,608 Citations2005Kebin Liu, Spencer V. Muse
PowerMarker delivers a data-driven, integrated analysis environment (IAE) for genetic data that accelerates the analysis lifecycle and enables users to maintain data integrity throughout the process.
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New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified in genetically predisposed individuals.
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Biological PsychologySex differences in HPA axis responses to stress: a review
1,577 Citations2004Brigitte M. Kudielka, Clemens Kirschbaum
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1,540 Citations2006Larry Cahill
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Life SciencesFree Cortisol Levels after Awakening: A Reliable Biological Marker for the Assessment of Adrenocortical Activity
1,434 Citations1997Jens C. Pruessner, Oliver T. Wolf +6 more
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Nature reviews. NeuroscienceGene–environment interactions in psychiatry: joining forces with neuroscience
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Opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene–environment interactions in psychiatry are discussed.
International Journal of PsychophysiologyThe cortisol awakening response (CAR): Facts and future directions
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It is hypothesized that the anticipation of the upcoming day is of major relevance for the magnitude of the cortisol awakening response, and considerations are addressed concerning the exact function of the CAR.
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It is found that the increase in cortisol following waking (CARi), and the integrated volume of cortisol released over the waking period (CARauc), was positively associated with job stress and general life stress and negatively related to posttraumatic stress syndrome.
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It is hypothesised that sex differences in HPAA and autonomic nervous system responses to acute psychosocial stress have to a great deal been driven by the need to protect the fetus from the adverse effects of maternal stress responses, in particular excess glucocorticoid exposure.
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889 Citations1992Regina Dressendörfer, Clemens Kirschbaum +3 more
A simple-to-perform synthesis yielded a conjugate suitable for use as a tracer in immunoassays for cortisol measurement and showed excellent correlation with a commercially available radioimmunoassay adapted for salivary cortisol measurement.
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The results indicate that corticosterone can alter the rations of neuropeptide mRNAs within individual cell type as well as alther the levels of a particular mRNA in the same or different directions in different cell types.
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