Immunology and Infectious Disease
Geriatric medicinePublished 1 January 1990
Edith Burns, James S. Goodwin
Citations44
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TL;DR
A tube of venous blood provides the immunologist with millions of cells with which to study antibody production, cytotoxicity, proliferation, migration, and other characteristics that are necessary for the continued health and survival of an organism.
Abstract
Immunologic function declines with age. Indeed, most physiologic functions decline with age. Why, then, has so much attention been given to the study of immunologic changes in elderly humans and laboratory animals? Immunologic function probably is the most intensively studied physiologic process in gerontology. Part of the reason has to do with the rapid growth in all aspects of immunologic research in the past 3 decades. In addition, immunocytes (lymphocytes, monocytes, and polymorphonuclear leukocytes) are the most easily obtained tissue specimens in humans. A tube of venous blood provides the immunologist with millions of cells with which to study antibody production, cytotoxicity, proliferation, migration, and other characteristics that are necessary for the continued health and survival of an organism.
Keywords
Immunology and Microbiology
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PsychosomaticsLife events and illness onset: A review
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31 Citations1984William B. Ershler, Ann L. Moore +4 more
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28 Citations1977Lauren Grace Mackey, Senga Whittingham +1 more
Age-related changes in man are particularly evident, structurally and functionally, in the thymus andThymus-dependent lymphocyte population as judged by several indices of integrity of the T cell system, whereas B cell functions appear to be relatively well preserved.
Cellular ImmunologyInduction of DNA synthesis in isolated nuclei by cytoplasmic factors from spontaneously proliferating and mitogen-activated lymphoid cells
27 Citations1983J K Gutowski, Stanley Cohen
Cytoplasmic extracts, prepared from continuously proliferating lymphoblastoid cells, as well as mitogen-activated normal lymphocytes, contain an extractable factor capable of inducing DNA synthesis in isolated quiescent nuclei that suggests that it serves as an intracellular mitogenic signal in replicating cells.
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26 Citations1978David I. Friedman, Amiela Globerson
Transfer of bone marrow cells from aged into young irradiated recipients indicated that cells capable of differentiation into antibody-producing cells are available during aging, and it was maintained that the defect at the B cell level is of a developmental nature.
Survey of Immunologic ResearchModulation of immune response in aged humans through different administration modes of thymopentin
25 Citations1985Jean Duchateau, G. Servais +3 more
The present study shows that the immunomodulating properties of thymopentin involve both specific and nonspecific responses in a population of elderly people vaccinated with keyhole limpet hemocyanin (KLH) antigen.
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24 Citations1986J K Gutowski, J B Innes +2 more
The results suggest that the depressed cellular reactivity of aged lymphocytes to PHA may be due to a failure of these nuclei to respond to cytoplasmic stimulatory signals induced by the mitogen.
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23 Citations1978Senga Whittingham, J D Buckley +1 more
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New England Journal of MedicineAmantadine as an Antiviral Agent in Influenza
16 Citations1982R. Gordon Douglas
Amantadine became the first antiviral agent available for systemic use in the United States when it was licensed by the Food and Drug Administration in 1966 for prophylaxis of Asian influenza (H2N2).
Immunoengineering: Prospects for Correction of Age-Related Immunodeficiency States
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A major extension of longest-lived survivorship by measures that can only be interpreted immunologically would constitute formal proof of the immunologic theory of aging, at least in terms of pathogenesis.
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15 Citations1977Takashi Makinodan
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14 Citations1987A McCormick, HilaryE. Tillett +2 more
The surveillance of cases of the acquired immune deficiency syndrome (AIDS) in the United Kingdom is described and a preliminary analysis made of the 1012 cases that were reported to the end of August 1987, showing no sign of slowing down.
JAMAHIV Antibody Screening in a General Hospital Population
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