Patient-Specific Decisions About Hormone Replacement Therapy in Postmenopausal Women
JAMAPublished 9 April 1997
Nananda F. Col
Citations236
SJR quartileQ1
SJR score5.35
SNIP10.71
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TL;DR
The benefit of hormone replacement therapy in reducing the likelihood of developing CHD appears to outweigh the risk of breast cancer for nearly all women in whom this treatment might be considered, and this analysis supports the broader use of hormones replacement therapy.
Abstract
The benefit of hormone replacement therapy in reducing the likelihood of developing CHD appears to outweigh the risk of breast cancer for nearly all women in whom this treatment might be considered. Our analysis supports the broader use of hormone replacement therapy.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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New England Journal of MedicinePostmenopausal Estrogen Therapy and Cardiovascular Disease
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CirculationAn updated coronary risk profile. A statement for health professionals.
1,864 Citations1991Keaven M. Anderson, P W Wilson +2 more
Using a simple worksheet, a patient's 5- and 10-year CHD risks can be estimated using components of the profile selected because they are objective and strongly and independently related to CHD.
Preventive MedicineEstrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence
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New England Journal of MedicineThe Use of Estrogens and Progestins and the Risk of Breast Cancer in Postmenopausal Women
1,509 Citations1995Graham A. Colditz, Susan E. Hankinson +7 more
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New England Journal of MedicineMenopause and the Risk of Coronary Heart Disease in Women
1,149 Citations1987Graham A. Colditz, Walter C. Willett +4 more
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Medical Decision MakingThe Markov Process in Medical Prognosis
973 Citations1983J. Robert Beck, Stephen G. Pauker
A general- purpose model of medical prognosis based on the Markov process is described and it is shown how this simple mathematical tool may be used to generate detailed and accurate assessments of life expectancy and health status.
Obstetrics and GynecologyHormone replacement therapy and endometrial cancer risk: A meta-analysis
957 Citations1995Deb Grady, Tebeb Gebretsadik +3 more
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New England Journal of MedicineA Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart Disease
855 Citations1985Meir J. Stampfer, Walter C. Willett +4 more
The hypothesis that the postmenopausal use of estrogen reduces the risk of severe coronary heart disease is supported.
Annals of Internal MedicineEstrogen Replacement Therapy and Fractures in Older Women
820 Citations1995Jane A. Cauley, Dana G. Seeley +4 more
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New England Journal of MedicineCardiovascular Health and Disease in Women
809 Citations1993Nanette K. Wenger, Leon Speroff +1 more
Lack of information about preventive strategies, diagnostic testing, responses to medical and surgical therapies, and other aspects of cardiovascular illness in women is compounded by the less frequent participation of women in research studies.
New England Journal of MedicineDecreased Risk of Fractures of the Hip and Lower Forearm with Postmenopausal Use of Estrogen
786 Citations1980Noel S. Weiss, Carol L. Ure +3 more
It is argued that lowering of the risk of hip and forearm fractures must be weighed as a benefit of long-term estrogen use.
Annals of Internal MedicineLong-Term Estrogen Replacement Therapy Prevents Bone Loss and Fractures
783 Citations1985Bruce Ettinger, HARRY K. GENANT +1 more
Comparing the occurrence of fractures in 245 long-term estrogen users and 245 case-matched controls, followed for an average of 17.6 years found that estrogen replacement therapy confers significant protection against bone loss and fracture.
JNCI Journal of the National Cancer InstituteThe Lifetime Risk of Developing Breast Cancer
635 Citations1993Eric J. Feuer, Lap‐Ming Wun +4 more
A revised method for calculating estimates of the lifetime risk of developing breast cancer and a conditional risk estimate over the short term (10 or 20 years) may be more reliable.
JAMAA Meta-analysis of the Effect of Estrogen Replacement Therapy on the Risk of Breast Cancer
635 Citations1991Karen Steinberg
To quantify the effect of estrogen replacement therapy on breast cancer risk, a combined dose-response slopes of the relative risk of breast cancer against the duration of estrogen use across 16 studies was combined.
Archives of Internal MedicineDecreased Mortality in Users of Estrogen Replacement Therapy
634 Citations1991B. E. Henderson
Obstetrical & Gynecological SurveyHip Fracture and the Use of Estrogens in Postmenopausal Women
628 Citations1988Douglas P. Kiel, David T. Felson +3 more
The hypothesis that postmenopausal use of estrogens protects against subsequent hip fracture in women is supported by this large cohort study of 2873 women in the Framingham Heart Study.
JAMAIncidence of and Treatment for Ductal Carcinoma In Situ of the Breast
601 Citations1996Virginia L. Ernster
Trends in incidence and treatment for ductal carcinoma in situ (DCIS) of the breast in the United States between 1973 and 1992 are described and total numbers of in situ cases diagnosed and numbers treated by mastectomy since 1983 are estimated.
JAMAEffects of Hormone Replacement Therapy on Endometrial Histology in Postmenopausal Women
595 Citations1996Howard L. Judd
Combining CEE with cyclic or continuous MPA or cyclic MP protected the endometrium from hyperplastic changes associated with estrogen-only therapy.
The American Journal of MedicineA convenient approximation of life expectancy (the “DEALE”)
475 Citations1982J. Robert Beck, Stephen G. Pauker +3 more
The DEALE method is used to obtain approximations of quality-adjusted life expectancy and the application of the method in a quantitative analysis of a clinical decision is illustrated.
Annals of Internal MedicineMenopausal Estrogen Therapy and Hip Fractures
470 Citations1981Annlia Paganini‐Hill, Ronald K. Ross +4 more
PubMedHip fracture mortality. Relation to age, treatment, preoperative illness, time of surgery, and complications.
466 Citations1984Kenzora Je, McCarthy Re +2 more
The LancetPOST-MENOPAUSAL $OElig;STROGENS PROTECT AGAINST FRACTURES OF HIP AND DISTAL RADIUS A Case-control Study
454 Citations1979Thomas H. Hutchinson
CancerContinued local recurrence of carcinoma 15–25 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy
433 Citations1995David L. Page, William D. Dupont +3 more
The stratification of ductal carcinoma in situ (DCIS) of the human breast into prognostically relevant categories by size and histologic pattern is a current concern and few studies have been able to follow women after the identification of any type of DCIS when they have had biopsy only.
PubMedSurveillance, epidemiology, and end results: incidence and mortality data, 1973-77.
417 Citations1981John L. Young, Constance Percy +1 more
The American Journal of MedicineA convenient approximation of life expectancy (the “DEALE”)
416 Citations1982J. Robert Beck, Jerome P. Kassirer +1 more
A simple approximation of life expectancy (the "DEALE") that is based on the assumption that survival follows a simple declining exponential function is described and it is shown that this approximation estimates life expectancy accurately for the great majority of clinical problems.
JNCI Journal of the National Cancer InstitutePerceptions of Breast Cancer Risk and Screening Effectiveness in Women Younger Than 50 Years of Age
410 Citations1995William C. Black, Robert F. Nease +1 more
A balanced presentation of information about breast cancer risk and screening effectiveness may improve decision making for women younger than 50 years of age and reduce their anxiety about Breast cancer, regardless of whether they choose to be screened.
American Journal of Public HealthRace and sex differences in hip fracture incidence.
402 Citations1984Mary E. Farmer, Lon R. White +2 more
Analysis based on an independent data source of non-federal hospital discharges in Washington, DC confirmed that White women were at twice the risk for hip fracture compared with Black women and at 2.7 times the risk compared to White men.
American Journal of Public HealthSurvival experience of aged hip fracture patients.
390 Citations1989Jay Magaziner, Eleanor M. Simonsick +3 more
The authors suggest that medical factors that may contribute to patient disorientation be investigated and treated, when possible, in an effort to improve the survival status of hip fracture patients.
Archives of Internal MedicineEstrogen Replacement and Coronary Artery Disease
373 Citations1990Jay M. Sullivan
JNCI Journal of the National Cancer InstituteEstrogen Replacement Therapy and Risk of Fatal Colon Cancer in a Prospective Cohort of Postmenopausal Women
361 Citations1995E. E. Calle, Heidi L. Miracle-McMahill +2 more
In the data, estrogen therapy, particularly recent and long-term use, was associated with a substantial decrease in risk of fatal colon cancer, consistent with several published studies suggesting a protective role of exogenous estrogens in the development of colorectal cancer.
BMJPostmenopausal oestrogen treatment and stroke: a prospective study.
349 Citations1988Annlia Paganini‐Hill, Rachael K. Ross +1 more
Oestrogen replacement treatment protects against death due to stroke in all age groups except the youngest and was unaffected by adjustment for possible confounding factors.
BJOG An International Journal of Obstetrics & GynaecologyThe risk of acute myocardial infarction after oestrogen and oestrogen‐progestogen replacement
343 Citations1992Margareta Falkeborn, Ingemar Persson +6 more
The relative risk of developing a first acute myocardial infarction after treatment with oestrogens alone or oestrogen‐progestogen combinations is determined.
JAMACombined Estrogen and Progestin Hormone Replacement Therapy in Relation to Risk of Breast Cancer in Middle-aged Women
343 Citations1995Janet L. Stanford
The use of estrogen with progestin HRT does not appear to be associated with an increased risk of breast cancer in middle-aged women, and future investigations must assess whether breast cancer incidence is altered many years after estrogen-progestin H RT has been initiated, particularly among long-term users.
American Journal of EpidemiologyAN EPIDEMIOLOGIC STUDY OF HIP FRACTURE IN POSTMENOPAUSAL WOMEN
340 Citations1982Nancy Kreiger, Jennifer L. Kelsey +2 more
The negative associations of hip fracture with estrogen replacement therapy, intact ovaries, and weight are consistent with the hypothesis that estrogens protect against hip fracture.
Acta Orthopaedica ScandinavicaAn Epidemiologic Study of Cervical and Trochanteric Fractures of the Femur in an Urban Population Analysis of 1,664 Cases with Special Reference to Etiologic Factors
317 Citations1964Per-Axel Alffram
PubMedRate of mortality for elderly patients after fracture of the hip in the 1980's.
312 Citations1987White Bl, Fisher Wd +1 more
The results suggest that there is an inverse relationship between mortality and advanced age and that the impact of a fracture of the hip on mortality is seen primarily in the first year after injury.
JAMABone Mineral Density and Risk of Breast Cancer in Older Women
290 Citations1996Jane A. Cauley
The findings suggest a link between 2 of the most common conditions affecting a woman's health and identifying a common denominator for these conditions should substantially improve the understanding of their etiology and prevention.
Annals of Internal MedicineDecision Analysis: A Progress Report
264 Citations1987Jerome P. Kassirer, ALAN J. MOSKOWITZ +2 more
Problems with the approach remain and applications have not been extensive, but decision analysis is evolving as a powerful clinical tool and gradually is gaining acceptance in medical practice.
JAMAThe Comparative Effect on Bone Density, Endometrium, and Lipids of Continuous Hormones as Replacement Therapy (CHART Study)
263 Citations1996Leon Speroff
Daily treatment with NA-EE2 was well tolerated and protected the endometrium from EE2-induced proliferation and hyperplasia and the overall effect of NA- EE2 treatments on lipid measures was favorable.
American Journal of Public HealthRace and sex differences in mortality following fracture of the hip.
259 Citations1992Steven J. Jacobsen, Jack Goldberg +4 more
The observed race-sex differences in survival were found at all ages and regardless of the number of comorbid conditions listed with the discharge diagnosis, and are not immediately apparent.
PubMedYounger women at increased risk for breast cancer: perceived risk, psychological well-being, and surveillance behavior.
245 Citations1994Caryn Lerman, Kathryn M. Kash +1 more
Preliminary data on risk perceptions, surveillance behaviors, and psychological well-being among women with a family history of breast cancer, with particular attention to younger women (under age 50), show that over three fourths of women aged 29 and younger hold the belief that they are likely to develop breast cancer.
American Journal of EpidemiologyPROGNOSIS AFTER BREAST CANCER DIAGNOSIS IN WOMEN EXPOSED TO ESTROGEN AND ESTROGEN-PROGESTOGEN REPLACEMENT THERAPY
244 Citations1989Leif Bergkvist, Hans‐Olov Adami +3 more
There is a possibility that exogenous female sex hormones affect survival in women with breast cancer, but several factors, particularly selection bias and surveillance bias, might have affected the results in favor of the women receiving hormone replacement therapy.
American Journal of Obstetrics and GynecologyEstrogen replacement therapy and protection from acute myocardial infarction
236 Citations1988Brian E. Henderson, Annlia Paganini‐Hill +1 more
As part of a longitudinal study of a southern California retirement community begun in June 1981, 8841 women 44 to 101 years old completed a health survey questionnaire, and as of January 1, 1987, 1019 deaths had occurred among these women.
Archives of Internal MedicineDecreased Risk of Stroke Among Postmenopausal Hormone Users
233 Citations1993Fanchon F. Finucane
It is suggested that post menopausal hormone use is associated with a decrease in risk of stroke incidence and mortality in white postmenopausal women.
JNCI Journal of the National Cancer InstitutePostmenopausal Hormone Use and Risk of Large-Bowel Cancer
230 Citations1995Polly A. Newcomb, Barry E. Storer
Use of HRT was associated with a statistically significant reduced risk of colon cancer, and no statistically significant relationship was observed for rectal cancer.
JAMAPostmenopausal Estrogen Use and Heart Disease Risk Factors in the 1980s
228 Citations1989Elizabeth Barrett-Connor
Current estrogen use was associated with lower weight, diastolic blood pressure, and fasting plasma glucose level than nonuse, and levels of low-density cholesterol were inversely related to estrogen dose; levels of high-density lipoprotein cholesterol were positively related to the duration of use.
Annals of Internal MedicineCost Effectiveness of Screening Perimenopausal White Women for Osteoporosis: Bone Densitometry and Hormone Replacement Therapy
222 Citations1990Anna N.A. Tosteson, Daniel I. Rosenthal +2 more
Screening asymptomatic, perimenopausal white women to detect low bone mass and to target hormone replacement therapy at women who are at the greatest risk for fracture is a reasonably cost-effective use of health care resources, according to a decision-analytic model.
Journal of Orthopaedic TraumaFactors Affecting Hip Fracture Mortality
219 Citations1987Stephen B. Sexson, James T. Lehner
It is felt that healthy patients should undergo surgery within 24 h of admission and less healthy patients can be stabilized medically before undergoing surgery without adding increased risk from the delay.
CirculationExpected gains in life expectancy from various coronary heart disease risk factor modifications.
215 Citations1991Joel Tsevat, Milton C. Weinstein +3 more
Population-wide gains in life expectancy from single risk-factor modifications are modest, but gains to individuals at risk can be more substantial.
Annals of Internal MedicineHormone Replacement Therapy and the Risk for First Hip Fracture
212 Citations1990Tord Naessén, Ingemar Persson +3 more
Treatment with potent estrogens, both alone and possibly when combined with progestogens, reduces the risk for both cervical and trochanteric hip fractures within the first decade after menopause.
Acta Orthopaedica ScandinavicaMortality and Life Expectancy After hip Fractures
211 Citations1980Eilif Dahl
The mortality rate was found to be high in the first 2 months following the fracture, but patients surviving the second month showed no excess mortality during the following 4 years, having the same life expectancy as the general population.
BJOG An International Journal of Obstetrics & GynaecologyCompliance with hormone replacement therapy (HRT) after screening for post menopausal osteoporosis
207 Citations1992Paul Ryan, R Harrison +2 more
Assessment of compliance with recommendations for hormone replacement therapy (HRT) in postmenopausal women following screening for osteoporosis finds that many women continue to receive HRT despite being told to do so by their GP.
PubMedEffect of weight, smoking, and estrogen use on the risk of hip and forearm fractures in postmenopausal women.
205 Citations1982Williams Ar, Weiss Ns +3 more
The beneficial effect of estrogen use in preventing both types of fracture varied considerably according to the woman's weight and smoking status, being greatest in thin women who smoked cigarettes and near zero in heavy nonsmokers.
EpidemiologyHip Fracture Incidence and Mortality in New England
191 Citations1991Elliott S. Fisher, John A. Baron +5 more
Hip fracture incidence among New England residents was higher among males, older patients, and those who had documented comorbidity or who were residents of nursing homes, and the female/male relative risk was greater among whites than among blacks.
New England Journal of MedicineAdding Insult to Injury
188 Citations1983Jerome P. Kassirer
It is the patient who endures or enjoys the outcomes of medical choices: the discomfort of diagnostic procedures, the disfigurement of surgery, the complications of drug therapy, and the joy of seemingly miraculous cures.
New England Journal of MedicineThe Toss-up
188 Citations1981Jerome P. Kassirer, Stephen G. Pauker
Paradigms are often created when expert physicians have different and strongly held opinions about the optimal treatment strategy for a given patient: sometimes a surgeon advocates medical therapy while the internist recommends surgery.
BMJCardioprotective effect of hormone replacement therapy in postmenopausal women: is the evidence biased?
165 Citations1994W F M Potshuma, Rudi G. J. Westendorp +1 more
Unintended selection of relatively healthy women for oestrogen therapy may have influenced the reported beneficial effect of oestrogens therapy on cardiovascular disease, and universal preventive hormonal replacement therapy for postmenopausal women is unwarranted at present.
JNCI Journal of the National Cancer InstituteCancer Patient Survival: Surveillance, Epidemiology, and End Results Program, 1973–79
158 Citations1983Lynn G. Ries, E S Pollack +1 more
Data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were used in the evaluation of cancer patient survival experience for almost 10% of the U.S. population, suggesting increasing rates for cancers of the colon, lung, and prostate gland, whereas there were no definite increases for cancer of the female breast and corpus uteri.
The American Journal of MedicinePostmenopausal estrogens in prevention of osteoporosis. Benefit virtually without risk if cardiovascular effects are considered
128 Citations1986Bruce E. Hillner, James P. Hollenberg +1 more
Estrogen therapy provides a significant gain in quality-adjusted life expectancy, and any recommendation about postmenopausal estrogens with respect to osteoporosis that excludes their cardiovascular effects markedly underestimates the potential gains from therapy.
Acta Orthopaedica ScandinavicaEarly failures among 14,009 cemented and 1,326 uncemented prostheses for primary coxarthrosis: The Norwegian Arthroplasty Register, 1987-1992
123 Citations1994Leif I Havelin, Birgitte Espehaug +2 more
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Obstetrics and Gynecology?
119 Citations1995Laurence C. Udoff
Combined continuous hormone replacement is well accepted by patients in clinical trials, effective in relieving vasomotor symptoms, and produces amenorrhea (though often after an initial period of irregular bleeding), an atrophic endometrium, and favorable changes in circulating lipids as well as maintaining bone density.
Journal of Epidemiology & Community HealthThe use of hormonal replacement therapy and the risk of stroke and myocardial infarction in women.
119 Citations1989S.G. Thompson, T W Meade +1 more
There is no evidence that the use of HRT as recently prescribed in the UK constitutes a major cardiovascular risk or benefit and the observed gradients of risk according to the duration and time since HRT use do not support a causal interpretation.
Obstetrics and GynecologyClinical and Biologic Prognostic Factors in Breast Cancer Diagnosed During Postmenopausal Hormone Replacement Therapy
111 Citations1995Pascal Bonnier
Regular surveillance during hormone replacement therapy reduces the number of locally advanced cancers and thus improves the survival rate and the distribution of hormone receptivity may reflect interaction between neoplastic tissue and exogenous hormones.
American Heart JournalAttitudes of women toward hormone therapy and prevention of heart disease
109 Citations1995Louise Pilote, Mark A. Hlatky
This study surveys 600 women who graduated from Stanford University between 1967 and 1971 about their attitudes toward the diseases that might be affected by hormone therapy and the women's perceived risk of development of heart disease and breast cancer.
The American Journal of MedicineComparison of physicians' decisions regarding estrogen replacement therapy for menopausal women and decisions derived from a decision analytic model
103 Citations1986Arthur S. Elstein, Gerald B. Holzman +6 more
The increased probability of early detection of cancer by regular follow-up was systematically incorporated into the decision analysis but apparently neglected in unaided clinical judgment, which follows the principle of minimizing the most important risk, regardless of its probability.
American Journal of Public HealthThe risk of hip fracture in postmenopausal females with or without estrogen drug exposure.
103 Citations1981Robert E. Johnson, Elmer E. Specht
The risk of hip fracture was reduced with postmenopausal and prefracture estrogen exposure, and a possible protective effect from estrogens was also suggested with oral estrogen exposure and with longer lengths of estrogen exposure.
Acta Orthopaedica ScandinavicaMortality after cervical hip fracture: 3002 patients followed for 6 years
98 Citations1986Sven Holmberg, Patrik Conradi +2 more
In 3002 patients with a femoral intracapsular neck fracture occurring during a 3-year period in the Stockholm area, 79% were admitted from home and the remainder from different types of institutions, where the mortality among these fracture patients was higher than in the general population.
The American Journal of MedicinePostmenopausal estrogen replacement: A long-term cohort study
95 Citations1994Fred W. Lafferty, Mary E. Fiske
Both ERT and total serum cholesterol had independent effects on the development of cardiovascular disease (myocardial infarction and stroke) in a multivariate analysis.
Archives of Internal MedicineClinical decision analysis by personal computer
90 Citations1981Stephen G. Pauker
A computer program is developed, implemented on a personal computer, that guides the physician in constructing and analyzing decision trees and simplifies the performance of sensitivity analysis, the process that assesses the probability and utility data used in an analysis.
Archives of Internal MedicineA Review of the Association of Estrogens and Progestins With Cardiovascular Disease in Postmenopausal Women
86 Citations1993Bruce M. Psaty
The lipid effects of estrogens in postmenopausal women probably prevent atherosclerosis, and it would expect long duration of use rather than current use to provide the greatest benefit, although few epidemiologic studies have assessed duration of estrogen use.
American Journal of Public HealthHealth status before and mortality after hip fracture.
81 Citations1996Annette Katelaris, Robert G. Cumming
A cohort study done to determine the direct impact of hip fracture on mortality in older people suggests that the observed excess mortality after hip fracture is not explained by poor prefracture health status.
Archives of Internal MedicineEstrogen replacement therapy. A survey of older women's attitudes
78 Citations1996L Salamone
International Journal of Gynecology & ObstetricsRelative risks and benefits of long‐term estrogen replacement therapy: A decision analysis
75 Citations1994Robin D. Gorsky, Jeffrey P. Koplan +2 more
Sensation analysis suggests that the benefits of estrogen replacement therapy outweigh the risks under most assumptions, and women using estrogen for 25 years would gain 3951 quality-adjusted life years compared with women not using estrogens.
Medical Decision MakingDecision Maker 3.0
73 Citations1983Joseph Lau, Jerome P. Kassirer +1 more
Decision MAKER°, a microcomputer program for performing clinical decision analyses, has been extensively revised, allowing the analyst to perform far more complex analyses.
American Journal of EpidemiologyESTROGEN USE AND STROKE RISK IN POSTMENOPAUSAL WOMEN1
73 Citations1976R. I. PFEFFER, Stanley van den Noort
Among postmenopausal women (58-98 years of age) in a retirement community use of oral estrogens was not significantly associated with overall risk of stroke and an observed association between estrogen use and nonembolic cerebral infarction in women aged 70-79 may be secondary to an interaction between hypertension and estrogen usage.
BMJRandomised comparison of oestrogen versus oestrogen plus progestogen hormone replacement therapy in women with hysterectomy
72 Citations1996T W Meade
Oestrogen plus progestogen was no less well tolerated than oestrogen alone and there was a fairly even balance between possibly beneficial and adverse effects of the two regimens on lipid concentrations and coagulability.
American Journal of Obstetrics and GynecologySuperior compliance and efficacy of continuous combined oral estrogen-progestogen replacement therapy in postmenopausal women
71 Citations1995Martina Dören, Gerd Reuther +2 more
Continuous combined therapy is superior to sequential estrogen progestogen replacement in compliance and prevention of bone loss but not with regard to relief of climacteric symptoms.
PubMedThe relationship between breast cancer survival and prior postmenopausal estrogen use.
70 Citations1992D M Strickland, R D Gambrell +2 more
It is concluded that prior postmenopausal estrogen replacement therapy does not compromise survival in women who subsequently develop carcinoma of the breast.
GerontologyTen-Year Survival after Fractures of the Proximal End of the Femur
65 Citations2009Stefan Elmerson, Carl Zetterberg +1 more
Two hundred and eighty-eight patients who sustained a fracture of the proximal end of the femur in 1975 were followed up for 10 years and age was the single most important factor determining long-term survival.
PubMedMenopausal hormone use and colorectal cancer in Saskatchewan: a record linkage cohort study.
62 Citations1995Harvey A. Risch, Geoffrey R. Howe
This study provides little evidence that usage of menopausal hormones may be related to risk of colorectal cancer (either positively or negatively), though further follow-up of the cohort appears warranted.
PubMedThe probability of death following a fracture of the hip.
58 Citations1971Peter Gordon
Mortality was greatest in males in those 75 years of age and over and especially in patients who were relatively immobilized prior to their fracture, in this "dependent" group the relative survival ratio at one year was only 38%.
The Medical Journal of AustraliaColorectal cancer and oestrogen replacement therapy: A meta‐analysis of epidemiological studies
49 Citations1995Suzanna C. MacLennan, Alastair H. MacLennan +1 more
To determine if non‐contraceptive oestrogen replacement therapy alters the risk of colorectal cancer, a large number of women treated with this therapy have had their ovaries removed.
American Journal of Obstetrics and GynecologyEstrogen and interrupted progestin: A new concept for menopausal hormone replacement therapy
46 Citations1993Robert F. Casper, Alcide Chapdelaine
Preliminary results of low bleeding rates, good symptom control, and endometrial protection suggest that hormone replacement with low-dose estrogen and interrupted progestin is effective and may lead to improved compliance in menopausal women.
Baillière s Clinical Obstetrics and Gynaecology12 Cost-effectiveness of hormone replacement therapy after the menopause
46 Citations1991Anna N.A. Tosteson, Milton C. Weinstein
Unless combined therapy is found to confer protection against ischaemic heart disease, the most cost-effective strategies for women with no prior hysterectomy may involve screening perimenopausal women to detect women at highest risk of hip fracture followed by selective treatment.
Medical Decision MakingLife Expectancy Biases in Clinical Decision Modeling
40 Citations1995Karen M. Kuntz, Milton C. Weinstein
The authors found that life expectancies and incremental cost-effectiveness ratios differed depending on whether an excess-mortality or a proportional-hazards model was specified, which resulted in non- optimal decisions in the long run.
Journal of General Internal MedicineHow do physicians weigh iatrogenic complications?
37 Citations1994Brian J. Cohen, Stephen G. Pauker
In making decisions, some physicians appear to weigh errors of commission more heavily than they do errors of omission, while others weigh them equally; this diversity of physicians’ attitudes may explain some of the variation observed in clinical practice in settings where the possibility of iatrogenic complications is of concern.
JAMAHormone Replacement and Breast Cancer
36 Citations1995Hans‐Olov Adami
Ever since replacement hormones were introduced some 30 years ago, there has been concern regarding a possible adverse effect on breast cancer risk, but some recent studies indicate that long-term intake of conjugated estrogens or estradiol compounds is associated with a moderate risk increase.
PubMedEstimated gains in life expectancy with use of postmenopausal estrogen therapy: a decision analysis.
18 Citations1993Zubialde Jp, F H Lawler +1 more
Substantial increases in life expectancy may result from postmenopausal estrogen therapy, and these may be equal to or possibly greater than benefits from other well-recognized risk-reduction strategies.
JAMAAntilymphoblastic Globulin in Renal Transplant Patients: No Allergic Reactions: A Correction
14 Citations1995Shelley N. Chou
The University of Minnesota wishes to correct the public record regarding Richard Condie, a recent federal indictment named Mr Condie and others regarding unreported deaths of patients associated with administration of antilymphoblast globulin.
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