Citation classics in critical care medicine
Intensive Care MedicinePublished 24 February 2004Open access
Anja Baltussen, Christoph Kindler
Citations208
SJR quartileQ1
SJR score5.00
SNIP6.11
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TL;DR
A historical perspective on the scientific progress of critical care medicine is given and the characteristics of the most frequently cited articles in the field are examined to allow for recognition of important advances in this specialty.
Abstract
Our analysis gives a historical perspective on the scientific progress of critical care medicine and allows for recognition of important advances in this specialty.
Keywords
Decision SciencesArts and Humanities
Critical Care MedicineAPACHE II-A Severity of Disease Classification System
13,396 Citations1986William A. Knaus, Elizabeth A. Draper +2 more
The form and validation results of APACHE II, a severity of disease classification system, are presented, showing an increasing score was closely correlated with the subsequent risk of hospital death for 5815 intensive care admissions from 13 hospitals.
CHEST JournalDefinitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
13,045 Citations1992Roger C. Bone, R.A. Balk +6 more
Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized, and the use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality.
New England Journal of MedicineVentilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
12,905 Citations2000The Acute Respiratory Distress Syndrome Network
In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
PubMedThe injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.
8,022 Citations1974Susan P. Baker, Brian O’Neill +2 more
The LancetASSESSMENT OF OUTCOME AFTER SEVERE BRAIN DAMAGE A Practical Scale
7,511 Citations1975B. Jennett
American Journal of Respiratory and Critical Care MedicineThe American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination
6,782 Citations1994Gordon R. Bernard, Antonio Artigas +8 more
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality, and financial cost.
JAMAA new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
6,363 Citations1993J. R. Le Gall
The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis, and is a starting point for future evaluation of the efficiency of intensive care units.
New England Journal of MedicineEfficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
6,122 Citations2001Gordon R. Bernard, Jean‐Louis Vincent +9 more
Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding.
American Journal of Infection ControlCDC definitions for nosocomial infections, 1988
5,776 Citations1988Julia S. Garner, William R. Jarvis +3 more
The Centers for Disease Control (CDC) has developed a new set of definitions for surveillance of nosocomial infections that combine specific clinical findings with results of laboratory and other tests that include recent advances in diagnostic technology.
The LancetACUTE RESPIRATORY DISTRESS IN ADULTS
4,203 Citations1967D G Ashbaugh, D. Boyd Bigelow +2 more
Positive end-expiratory pressure was most helpful in combating atelectasis and hypoxaemia and Corticosteroids appeared to have value in the treatment of patients with fat-embolism and possibly viral pneumonia.
JAMAA controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). The SUPPORT Principal Investigators
2,779 Citations1995Alfred F. Connors, Neal V. Dawson +198 more
The phase I observation of SUPPORT confirmed substantial shortcomings in care for seriously ill hospitalized adults and the phase II intervention failed to improve care or patient outcomes.
American Review of Respiratory DiseaseAn Expanded Definition of the Adult Respiratory Distress Syndrome
2,657 Citations1988John F. Murray, Michael A. Matthay +2 more
An expanded definition of ARDS is proposed that takes into account new knowledge about adult respiratory distress syndrome and its clinical features, physiologic disturbances, prognosis, and pathologic findings.
Critical Care MedicineMultiple Organ Dysfunction Score
2,536 Citations1995John C. Marshall, Deborah J. Cook +4 more
This multiple organ dysfunction score, constructed using simple physiologic measures of dysfunction in six organ systems, mirrors organ dysfunction as the intensivist sees it and correlates strongly with the ultimate risk of ICU mortality and hospital mortality.
NatureAnti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
2,471 Citations1987Kevin J. Tracey, Yuman Fong +6 more
Protection against shock, vital organ dysfunction, persistent stress hormone release and death was conferred by administration of antibodies 2 h before bacterial infusion, indicating that cachectin is a mediator of fatal bacteraemic shock and suggesting that antibodies against Cachectin offer a potential therapy of life-threatening infection.
The Journal of Trauma: Injury, Infection, and Critical CareProblems in the Management of Type III (Severe) Open Fractures
2,369 Citations1984Ramon B. Gustilo, Rex M. Mendoza +1 more
It is recommended that the current designation of Type III open fracture be divided, in order of worsening prognosis, into three subtypes, because of varied severity and prognosis.
American Journal of Respiratory and Critical Care MedicineVentilator-induced Lung Injury: Lessons from Experimental Studies
2,299 Citations1998Didier Dreyfuss, Georges Saumon
This paper presents experimental evidence for Increased Vascular Transmural Pressure Evidence for Alterations in Alveolar–Capillary Permeability Contributions of the Static and Dynamic Lung Volume Components to Ventilator-induced Edema High-volume Lung Edema Low Lung Volume Injury.
JAMAThe Effectiveness of Right Heart Catheterization in the Initial Care of Critically III Patients
2,212 Citations1996Alfred F. Connors
The Journal of Trauma: Injury, Infection, and Critical CareTHE ROLE OF SECONDARY BRAIN INJURY IN DETERMINING OUTCOME FROM SEVERE HEAD INJURY
2,185 Citations1993Randall M. Chesnut, Lawrence F. Marshall +7 more
The increased morbidity and mortality related to severe trauma to an extracranial organ system appeared primarily attributable to associated hypotension, and improvements in trauma care delivery over the past decade have not markedly altered the adverse influence of hypotension.
Critical Care MedicineAPACHE—acute physiology and chronic health evaluation: a physiologically based classification system
2,173 Citations1981William A. Knaus, Jack E. Zimmerman +3 more
The development and initial validation of acute physiology and chronic health evaluation (APACHE), a physiologically based classification system for measuring severity of illness in groups of critically ill patients, is described.
New England Journal of MedicineCatheterization of the Heart in Man with Use of a Flow-Directed Balloon-Tipped Catheter
2,119 Citations1970H. J. C. Swan, William Ganz +4 more
JAMACLOSED-CHEST CARDIAC MASSAGE
2,088 Citations1960W. B. Kouwenhoven
Anyone, anywhere, can now initiate cardiac resuscitative procedures to give not only mouth-to-nose artificial respiration but also adequate cardiac massage without thoracotomy.
New England Journal of MedicineA Semiquantitative Culture Method for Identifying Intravenous-Catheter-Related Infection
2,064 Citations1977Dennis G. Maki, Carol E. Weise +1 more
The semiquantitative technic distinguishes infection (greater than or equal to 15 colonies) from contamination and is more specific in diagnosis of catheter-related septicemia than culture of the catheter in broth.
PubMedEvaluating trauma care: the TRISS method. Trauma Score and the Injury Severity Score.
1,976 Citations1987Carl Boyd, M Tolson +1 more
This article is a source for those interested in developing or upgrading trauma care evaluation, as well as a means of comparison of outcome for different populations of trauma patients.
The Journal of Trauma: Injury, Infection, and Critical CareA Revision of the Trauma Score
1,937 Citations1989Howard R. Champion, William J. Sacco +4 more
T-RTS, the sum of coded values of GCS, SBP, and RR, demonstrated increased sensitivity and some loss in specificity when compared with a triage criterion based on TS and GCS values, and RTS demonstrated substantially improved reliability in outcome predictions compared to the TS.
New England Journal of MedicineInhaled Nitric Oxide for the Adult Respiratory Distress Syndrome
1,834 Citations1993Rolf Rossaint, K. J. Falke +4 more
Inhalation of nitric oxide by patients with severe adult respiratory distress syndrome reduces the pulmonary-artery pressure and increases arterial oxygenation by improving the matching of ventilation with perfusion, without producing systemic vasodilation.
CHEST JournalProspective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients
1,799 Citations1988William C. Shoemaker, Paul L. Appel +3 more
The hypothesis was proposed that increased CI and DO2 are circulatory compensations for increased postoperative metabolism and this hypothesis was tested in two series, finding that the PA-protocol group mortality was significantly reduced compared with its control group.
New England Journal of MedicineTreatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin
1,625 Citations1991Elizabeth Ziegler, Charles J. Fisher +14 more
HA-1A is safe and effective for the treatment of patients with sepsis and gram-negative bacteremia and analyses that stratified according to the severity of illness at entry showed improved survival with HA- 1A treatment in both severely ill and less severely ill patients.
New England Journal of MedicinePathogenetic Mechanisms of Septic Shock
1,560 Citations1993Franklin H. Epstein, Joseph E. Parrillo
One of the most frequent and serious problems confronting clinicians is the management of a serious infection and the systemic response to infection, a syndrome termed sepsis, when this syndrome results in hypotension and organ dysfunction, called septic shock.
Critical Care MedicineNosocomial infections in medical intensive care units in the United States
1,557 Citations1999Michael J. Richards, Jonathan R. Edwards +2 more
The distribution of sites of infection in medical ICUs differed from that previously reported in NNIS ICU surveillance studies, largely as a result of anticipated low rates of surgical site infections.
New England Journal of MedicineA Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock
1,450 Citations1987Roger C. Bone, Charles J. Fisher +5 more
It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock.
The Journal of Trauma: Injury, Infection, and Critical CareTHE INJURY SEVERITY SCORE
1,424 Citations1976Susan P. Baker, Brian O’Neill
The injury severity score has changed little in the past decade, but the number of hospital admissions and the severity of the injuries has changed significantly.
Critical Care MedicinePediatric risk of mortality (PRISM) score
1,393 Citations1988Murray M. Pollack, Urs E. Ruttimann +1 more
The Pediatric Risk of Mortality (PRISM) score was developed from the Physiologic Stability Index (PSI) to reduce the number of physiologic variables required for pediatric ICU (PICU) mortality risk assessment and to obtain an objective weighting of the remaining variables.
Annals of SurgeryMultiple Organ Failure Pathophysiology and Potential Future Therapy
1,389 Citations1992Edwin A. Deitch
The goals of this review are to integrate the vast amount of new information on the basic biology of MOF and to focus special attention on the potential therapeutic consequences of these recent advances in the authors' understanding of this complex and perplexing syndrome.
New England Journal of MedicineOptimum End-Expiratory Airway Pressure in Patients with Acute Pulmonary Failure
1,301 Citations1975Peter M. Suter, H. Barrie Fairley +1 more
To determine whether in the management of pulmonary failure, the maximum compliance produced by positive end-expiratory pressure coincides with optimum lung function, 15 normovolemic patients requiring mechanical ventilation for acute pulmonary failure were studied.
Critical Care MedicineA simplified acute physiology score for ICU patients
1,271 Citations1984Jean‐Roger Le Gall, P. Loirat +7 more
The simplified acute physiology score (SAPS), evaluated in 679 consecutive patients admitted to eight multidisciplinary referral ICUs in Francece, was a simpler and less time-consuming method for comparative studies and management evaluation between different ICUs.
American Journal of Respiratory and Critical Care MedicineTidal Ventilation at Low Airway Pressures Can Augment Lung Injury
1,244 Citations1994John Muscedere, J. Brendan M. Mullen +2 more
End-expiratory lung volume is an important determinant of the degree and site of lung injury during positive-pressure ventilation as ventilation occurs from below to above the infection point (Pinf) as determined from the inspiratory pressure-volume curve.
Annals of SurgeryPrognosis in Acute Organ-System Failure
1,239 Citations1985William A. Knaus, Elizabeth A. Draper +2 more
The high death rates associated with acute OSF and the rapidity with which mortality increases over time are emphasized and reference data for physicians treating similar patients are provided.
Critical Care MedicineTherapeutic intervention scoring system
1,202 Citations1974David J. Cullen, Joseph M. Civetta +2 more
If other intensivists incorporate this system into their experience, meaningful comparisons between intensive care units can occur and the cost of intensive care relative to the extent of care offered can occur.
American Journal of Respiratory and Critical Care MedicineComparison of Three Methods of Gradual Withdrawal from Ventilatory Support During Weaning from Mechanical Ventilation
1,137 Citations1994Laurent Brochard, Alain Rauss +6 more
A randomized trial in three intensive care units in mechanically ventilated patients who met standard weaning criteria found a lower number of failures was found with PSV than with the other two modes, with the difference just reaching the level of significance.
PubMedThe Major Trauma Outcome Study: establishing national norms for trauma care.
1,109 Citations1990H R Champion, Wayne S. Copes +6 more
The LancetASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE
1,097 Citations1987Anders Waage, Alfred Halstensen +1 more
Annals of Internal MedicineNosocomial Respiratory Infections with Gram-Negative Bacilli
1,091 Citations1972W. G. Johanson, ALAN K. PIERCE +2 more
The Journal of Trauma: Injury, Infection, and Critical CareOrgan Injury Scaling
1,069 Citations1989Ernest E. Moore, Steven R. Shackford +9 more
The Organ Injury Scaling (O.I.S.) Committee of the American Association for the Surgery of Trauma (A.A.S.T.) was appointed by President Trunkey at the 1987 Annual Meeting to devise injury severity scores for individual organs to facilitate clinical research.
New England Journal of MedicineTreatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a Mutant<i>Escherichia coli</i>
1,054 Citations1982Elizabeth Ziegler, J. Allen McCutchan +5 more
It is concluded that human antiserum to the lipopolysaccharide core can substantially reduce deaths from gram-negative bacteremia.
American Journal of Respiratory and Critical Care MedicineRandomized Clinical Trial of Pressure-Controlled Inverse Ratio Ventilation and Extracorporeal CO2 Removal for Adult Respiratory Distress Syndrome
966 Citations1994Alan H. Morris, C. Jane Wallace +18 more
It is concluded that there was no significant difference in survival between the mechanical ventilation and the extracorporeal CO2 removal groups, and extracordoreal support for ARDS should be restricted to controlled clinical trials.
Intensive Care MedicineLow mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome
934 Citations1990Keith G. Hickling, Seton Henderson +1 more
American Journal of Respiratory and Critical Care MedicineRandomized, Prospective Trial of Noninvasive Positive Pressure Ventilation in Acute Respiratory Failure
921 Citations1995Naomi R. Kramer, Thomas J. Meyer +3 more
Noninvasive positive pressure ventilation administered by nasal or oronasal mask avoids the need for endotracheal intubation, rapidly improves vital signs, gas exchange, and sense of dyspnea, and may reduce mortality in selected patients with acute respiratory failure.
The Journal of Trauma: Injury, Infection, and Critical CareThe Injury Severity Score Revisited
905 Citations1988Wayne S. Copes, Howard R. Champion +4 more
The present study uses the most recent AIS version (AIS-85) to derive relationships between mortality rate and the iss for comtemporary patients with blunt or penetrating injuries and identifies important properties of the iss which should be considered when the measure is used to compare case mix severity in different populations.
New England Journal of MedicineSurvival after Cardiopulmonary Resuscitation in the Hospital
860 Citations1983Susanna E. Bedell, Thomas L. Delbanco +2 more
A multivariate analysis revealed that pneumonia, hypotension, renal failure, cancer, and a home-bound life style before hospitalization were significantly associated with in-hospital mortality.
The LancetGastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients
857 Citations1992Guillermo Gutiérrez, Fernando Pálizas +13 more
The Journal of Trauma: Injury, Infection, and Critical CareTEN versus TPN following Major Abdominal Trauma—Reduced Septic Morbidity
822 Citations1989Frederick A. Moore, Ernest E. Moore +3 more
This clinical study demonstrates that TEN is well tolerated in the severely injured, and that early feeding via the gut reduces septic complications in the stressed patient.
Annals of Internal MedicineAdult Respiratory Distress Syndrome: Risk with Common Predispositions
790 Citations1983Alpha A. Fowler, RICHARD F. HAMMAN +6 more
A 1-year survey of patients in three hospitals identified 936 patients who had one predisposition and 57 who had several predispositions to the adult respiratory distress syndrome, and 68 subsequently developed the syndrome.
The American Journal of CardiologyA new technique for measurement of cardiac output by thermodilution in man
766 Citations1971William Ganz, ROBERTO DONOSO +3 more
Comparison with cardiac outputs determined simultaneously by the dye-dilution technique (CODYE) in 63 measurements in 20 patients showed close agreement of the 2 methods in a range of values from 2.9 to 8.0 liters/min.
Critical Care MedicineEffects of inhaled nitric oxide in patients with acute respiratory distress syndrome
760 Citations1998R. Phillip Dellinger, Janice L. Zimmerman +7 more
Inhaled NO appears to be well tolerated in the population of ARDS patients studied and is associated with a significant improvement in oxygenation compared with placebo over the first 4 hrs of treatment.
Journal of Critical CareTotal parenteral nutrition promotes bacterial translocation from the gut
748 Citations1989J C Alverdy, Eric Aoys +1 more
Parenteral nutrition promotes bacterial translocation from the gut by increasing the cecal bacterial count and impairing intestinal defense, independent of route.
Archives of SurgeryMultiple System Organ Failure
743 Citations1980Donald E. Fry
Evaluation of multiple factors demonstrated that MSOF is primarily due to infection, the temporal sequence of organ failure is lung, liver, gastric mucosa, and kidney, andMSOF is the most common fatal expression of uncontrolled infection.
JAMAA Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis
741 Citations1991Richard L. Greenman
Treatment with E5 antiendotoxin antibody appears safe and reduces mortality and enhances the resolution of organ failure among patients with gram-negative sepsis who are not in shock when treated.
The LancetLow-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn
725 Citations1992John P. Kinsella
Nine newborn infants with severe persistent pulmonary hypertension who were candidates for extracorporeal membrane oxygenation treatment with low doses of NO showed rapid improvement in oxygenation without reduction of systemic blood pressure.
Intensive Care MedicineThe effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients
716 Citations1984C. P. Stoutenbeek, H. K. F. van Saene +2 more
Multiple trauma patients staying in the ICU for 5 or more days and needing mechanical ventilation were investigated to determine the effect of selective decontamination of the digestive tract on prevention of infection.
The Journal of Trauma: Injury, Infection, and Critical CareBenefits of Immediate Jejunostomy Feeding after Major Abdominal Trauma???A Prospective, Randomized Study
714 Citations1986Ernest E. Moore, Todd N. Jones
The clinical experience demonstrates the feasibility of immediate postoperative enteral feeding via N.C.N.J. after major abdominal trauma, and suggests this early nutrition reduces septic complications in critically injured patients.
Critical Care MedicineLow mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: A prospective study
701 Citations1994Keith G. Hickling, J. Walsh +2 more
To evaluate the outcome in patients with severe adult respiratory distress syndrome managed with limitation of peak inspiratory pressure to 30 to 40 cm H2O, low tidal volumes, spontaneous breathing using synchronized intermittent mandatory ventilation from the start.
PubMedSepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.
699 Citations1989R C Bone, Charles J. Fisher +4 more
The sepsis syndrome represents a systemic response to infection and is defined as hypothermia or hyperthermia, tachycardia, tachypnea, clinical evidence of an infection site and with at least one end-organ demonstrating inadequate perfusion or dysfunction expressed as poor or altered cerebral function.
PubMedRisk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation.
690 Citations1986D. E. Craven, Laureen M. Kunches +4 more
Ventilator-associated pneumonia was 1 of 18 variables univariately associated with overall patient fatality, but it was not among the 7 variables present after multivariate analysis.
American Review of Respiratory DiseaseState of the Art
658 Citations1983Robert M. Tate, John E. Repine
Critical Care MedicineAnti-inflammatory therapies to treat sepsis and septic shock
657 Citations1997Fabrice Zéni, Bradley D. Freeman +1 more
Annals of Internal MedicineMultiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome
641 Citations1983Randall C. Bell, JACQUELINE J. COALSON +2 more
Vigorous evaluation and treatment of infection in patients with the adult respiratory distress syndrome may improve survival and be more common in infected patients than noninfected patients.
American Journal of Respiratory and Critical Care MedicineBeneficial Effects of the "Open Lung Approach" With Low Distending Pressures in Acute Respiratory Distress Syndrome. A Prospective Randomized Study on Mechanical Ventilation
626 Citations1995Marcelo B. P. Amato, Carmen Sílvia Valente Barbas +8 more
It is concluded that the NA ventilatory strategy can markedly improve the lung function in patients with ARDS, increasing the chances of early weaning and lung recovery during mechanical ventilation.
Critical Care MedicineMechanisms of ventilator-induced lung injury
620 Citations1993James C. Parker, L. A. Hernandez +1 more
The physiologic mechanisms of ventilator-induced lung injury are described and the major ventilators and host-dependent risk factors that contribute to such injury are defined.
Medical CareThe Abbreviated Injury Scale and Injury Severity Score
617 Citations1985Ellen J. MacKenzie, Sam Shapiro +1 more
Results showed that as a group, physicians and nurses tend to be more reliable in their ratings than either emergency medical technicians (EMTs) or nonclinical technicians, although a research assistant who is well trained in AIS coding and is a diligent worker can use the AIS to code severity as reliably as the physicians when sufficient information is provided in the medical chart.
Critical Care MedicineToward a theory regarding the pathogenesis of the systemic inflammatory response syndrome
610 Citations1996Roger C. Bone
While cytokines are generally viewed as a destructive development in the patient that generally leads to multiple organ dysfunction, cytokines also protect the body when localized and it will be necessary to study the positive effects of cytokines while also studying their role in causing SIRS.
Critical Care MedicineLactic acidosis in critical illness
597 Citations1992Barry A. Mizock, Jay L. Falk
The severity of lactic acidosis in critically ill patients correlates with overall oxygen debt and survival, and lactate determinations may be useful as an ongoing monitor of perfusion as resuscitation proceeds.
Critical Care MedicineEarly enteral administration of a formula (Impact Registered Trademark) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients
589 Citations1995Robert H. Bower, Frank B. Cerra +8 more
Early enteral feeding of the experimental formula was safe and well tolerated in ICU patients and a substantial reduction in hospital length of stay was observed, along with a significant reduction in the frequency of acquired infections.
Critical Care MedicineA genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis
552 Citations1996Frank Stüber, Morten Rønn Petersen +2 more
The bi-allelic Ncol polymorphism within the TNF locus is a genomic marker for patients with increased TNF-alpha response and poor prognosis in severe sepsis.
Journal of NeurotraumaA Phase II Study of Moderate Hypothermia in Severe Brain Injury
541 Citations1993Guy L. Clifton, Steven J. Allen +7 more
The Journal of Trauma: Injury, Infection, and Critical CareA STANDARD ANIMAL BURN
534 Citations1968HARREL L. WALKER, Arthur D. Mason
Critical Care MedicineINTERSEPT
497 Citations1996Jonathan Cohen, Jean Carlet
IntERSEPT provides additional clinical data implicating TNF-alpha as an integral mediator of septic shock and suggested a possible role for anti-TNF antibody as adjunctive therapy, but this possibility requires confirmation by another clinical trial.
The Journal of Trauma: Injury, Infection, and Critical CareGut Bacterial Translocation via the Portal Vein
493 Citations1991Frederick A. Moore, Ernest E. Moore +5 more
This prospective clinical study has not confirmed portal or systemic bacteremia within the first 5 days postinjury, despite an eventual 30% incidence of MOF.
The Journal of Trauma: Injury, Infection, and Critical CareMultiple Organ Failure in Polytrauma Patients
493 Citations1983Eugen Faist, Arthur E. Baue +2 more
Earlier pulmonary and cardiovascular support beginning at the scene of the accident, and prevention and better treatment of head injury, respiratory failure, and sepsis are critical factors for increasing survival after injury.
Critical Care MedicineTumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans
488 Citations1989Pierre Damas, A. Reuter +4 more
There was a correlation between TNF alpha level and sepsis severity score as well as with mortality, and IL-1 beta serum levels were only slightly increased and were not correlated with severity or mortality.
Critical Care MedicineInitial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial
487 Citations1994Charles J. Fisher, Gus J. Slotman +7 more
This initial evaluation suggests that human recombinant IL‐lra is safe and may provide a dose‐related survival advantage to patients with sepsis syndrome.
American Journal of Respiratory and Critical Care MedicineEvidence for <i>In Vivo</i> Peroxynitrite Production in Human Acute Lung Injury
484 Citations1995Neil W. Kooy, James A. Royall +3 more
It is demonstrated that nitrogen-derived oxidants are formed in human acute lung injury and suggested that peroxynitrite may be an important oxidant in inflammatory lung disease.
ShockTHE PATHOPHYSIOLOGICAL ROLE OF PEROXYNITRITE IN SHOCK, INFLAMMATION, AND ISCHEMIA-REPERFUSION INJURY
479 Citations1996Csaba Szabó
Pharmacological evidence suggests that the peroxynitrite-poly-ADP ribosyl synthetase pathway importantly contributes to the cellular injury in endotoxic shock, inflammatory pancreatic islet cell destruction, and central nervous system ischemia.
The Journal of Trauma: Injury, Infection, and Critical CareAggressive Nutritional Support Does Not Prevent Protein Loss Despite Fat Gain in Septic Intensive Care Patients
474 Citations1987Stephen Streat, A H Beddoe +1 more
It is concluded that substantial losses of body protein occur in critically ill septic patients despite aggressive nutritional support and that further research is urgently required on the fate of infused substrates and the efficacy of alternative nutritional therapies.
American Journal of Respiratory and Critical Care MedicineMarked Flow-Dependence of Exhaled Nitric Oxide Using a New Technique to Exclude Nasal Nitric Oxide
470 Citations1997Philip E. Silkoff, Patricia McClean +7 more
There is a marked flow dependence of exhaled NO concentration and excretion, and exhaled pulmonary NO is best measured at very low flow rates to amplify the signal and must be related to the expiratory flow employed.
Critical Care MedicineA new stroke volume equation for thoracic electrical bioimpedance
460 Citations1986Donald P. Bernstein
A new stroke volume equation for thoracic electrical bioimpedance is proposed, which is modeled geometrically as a frustum (truncated cone), rather than a cylinder, and employs a percentage of overall body height in lieu of a measuredThoracic length.
The Journal of Trauma: Injury, Infection, and Critical CareCerebral Perfusion Pressure Management in Head Injury
459 Citations1990Michael J. Rosner, Sheila Daughton
Journal of Critical CareLung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance
453 Citations1987
Critical Care MedicineInfluence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis
431 Citations1993Charles J. Fisher, Steven M. Opal +17 more
The murine monoclonal anti-TNF antibody was well tolerated despite the development of anti-murine antibodies in 98% of patients and no survival benefit was found for the total study population.
Critical Care MedicineMechanisms of ischemic brain damage
426 Citations1988Bo K. Siesjö
This article provides a brief review of recent developments regarding the pathophysiology of ischemic brain damage, and offers hypotheses explaining the pathogenesis of selective neuronal vulnerability and of tissue infarction, respectively.
PubMedFluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock.
397 Citations1983Eric C. Rackow, Jay L. Falk +6 more
The Journal of Trauma: Injury, Infection, and Critical CareHemorrhagic Shock Induces Bacterial Translocation from the Gut
392 Citations1988John W. Baker, Edwin A. Deitch +3 more
Hemorrhagic shock followed by reinfusion of shed blood disrupts the gut barrier and allows indigenous bacteria normally contained within the gut to cause systemic infections.
World Journal of SurgeryOne Hundred Citation Classics in General Surgical Journals
391 Citations2002Ramesh Paladugu, Moshe Schein +2 more
To be well cited such a contribution should be published in the English language in a high-impact journal and more likely to resonant loudly if it originates from a North American or British "ivory tower."
Critical Care MedicineCritical level of oxygen delivery in anesthetized man
386 Citations1983K. Shibutani, Toru Komatsu +4 more
A decrease of Vo2 at Do2 less than 330 ml/min M2 suggests tissue oxygen deprivation occurred, and mixed venous oxygen tension (P&OV0456;O2) decreased in proportion to the decrease in Do2, suggesting compensatory increase of oxygen extraction.
Critical Care MedicinePredictive value of the stomach wall pH for complications after cardiac operations
375 Citations1987Richard G. Fiddian-Green, Stephen P. Baker
It was found that acidosis in the stomach wall was the most sensitive predictor for complications and the specificity of this predictive test increased exponentially as the duration and degree of intramural acidosis increased.
NatureThe politics of publication
351 Citations2003Peter A. Lawrence
Authors, reviewers and editors must act to protect the quality of research in the face of threats to research integrity.
JAMA100 Citation Classics From The Journal of the American Medical Association
331 Citations1987Eugene Garfield
The 100 most-cited JAMA articles were identified using the 1955 through 1983 Science Citation Index of the Institute for Scientific Information, and the editorial committee used a combination of peer review and citation frequency to select 51 articles.
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