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Stress and Coping Factors Influence Tumor Growth

SciencePublished 3 August 1979
Lawrence S. Sklar, Hymie Anisman
Citations285
SJR quartileQ1
SJR score10.42
SNIP6.62

TL;DR

Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated and a single session of inescapable shock resulted in earlier tumor appearance, exaggeration of tumor size, and decreased survival time in recipient animals.

Abstract

Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated as a result of various stress regimens. A single session of inescapable shock resulted in earlier tumor appearance, exaggeration of tumor size, and decreased survival time in recipient animals. Escapable shock had no such effects. The effects of the inescapable shock were mitigated if mice received long-term shock treatment.

Keywords

MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology