Anticonvulsant effects of ivermectin in genetically-epileptic chickens
NeuropharmacologyPublished 1 October 1986
E C Crichlow
Citations29
SJR quartileQ1
SJR score1.59
SNIP1.17
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TL;DR
In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system.
Abstract
In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was dose-dependent. When combined with diazepam, ivermectin prolonged the anti-convulsant action of diazepam.
Keywords
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