Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators
Genes & DevelopmentPublished 15 September 1999Open access
Natalya Yudkovsky, Colin Logie, Steven Hahn, Craig L. Peterson
Citations234
SJR quartileQ1
SJR score4.00
SNIP1.43
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TL;DR
It is demonstrated that SWI/SNF activity can be targeted by gene-specific activators and that this recruitment can occur independently of Pol II holoenzyme.
Abstract
SWI/SNF is a chromatin remodeling complex that facilitates expression of a number of yeast genes. Here we demonstrate that SWI/SNF can be recruited from yeast nuclear extracts by a transcriptional activator. Recruitment is dependent on an activation domain but not on promoter sequences, TBP, or RNA polymerase II holoenzyme. We also show that acidic activation domains can target SWI/SNF remodeling activity. These results demonstrate that SWI/SNF activity can be targeted by gene-specific activators and that this recruitment can occur independently of Pol II holoenzyme.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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