Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current
SciencePublished 18 November 1988
Toru Takumi, Hiroaki Ohkubo, Shigetada Nakanishi
Citations519
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay.
Abstract
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.
Keywords
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