Independent and incremental value of coronary artery calcium for predicting the extent of angiographic coronary artery disease
Journal of the American College of CardiologyPublished 1 September 1999
Axel Schmermund, Ali E. Denktas, John A. Rumberger, Timothy F. Christian, Patrick F. Sheedy, Kent R. Bailey
Citations151
SJR quartileQ1
SJR score9.02
SNIP6.30
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Coronary calcium predicts the angiographic extent of CAD in symptomatic patients and provides independent and incremental information to the more conventional clinical parameters derived from SPECT or risk assessment.
Abstract
Coronary calcium predicts the angiographic extent of CAD in symptomatic patients and provides independent and incremental information to the more conventional clinical parameters derived from SPECT or risk assessment.
Keywords
Medicine
Journal of the American College of CardiologyQuantification of coronary artery calcium using ultrafast computed tomography
7,604 Citations1990Arthur S. Agatston, Warren R. Janowitz +4 more
Ultrafast computed tomography was used to detect and quantify coronary artery calcium levels in 584 subjects and was more sensitive than fluoroscopy, detecting coronary calcium in 90% versus 52% of patients.
Annals of Internal MedicineHeart Disease: A Textbook of Cardiovascular Medicine.
4,135 Citations1984
The Cardiovascular Disease and Disorders of other Organ Systems chapter discussesCardiovascular Disease in Special Populations, Disorders of the Heart, Pericardium and Pulmonary Vascular Bed, and Molecular Biology and Genetics.
New England Journal of MedicineCompensatory Enlargement of Human Atherosclerotic Coronary Arteries
3,592 Citations1987Seymour Glagov, Elliot Weisenberg +3 more
It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.
CirculationCan coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?
1,471 Citations1988William C. Little, M Constantinescu +5 more
Assessment of the angiographic severity of coronary stenosis may be inadequate to accurately predict the time or location of a subsequent coronary occlusion that will produce a myocardial infarction.
CirculationCoronary Artery Calcium Area by Electron-Beam Computed Tomography and Coronary Atherosclerotic Plaque Area
1,457 Citations1995John A. Rumberger, D.Brent Simons +3 more
This histopathologic study confirms an intimate relation between whole heart, coronary artery, and segmental coronary atherosclerotic plaque area and EBCT coronary calcium area but suggests that there is a threshold value for plaque area below which coronary calcium is either absent or not detectable by this methodology.
CirculationOur Preoccupation With Coronary Luminology
1,103 Citations1995Eric J. Topol, Steven E. Nissen
Evidence is outlined that the current preoccupation with coronary "luminology" may be misguided and a rational paradigm for future practice and investigation is proposed to achieve the desired clinical end point: promoting survival and long-term freedom from myocardial infarction and the disabling symptoms of coronary heart disease.
Journal of the American College of CardiologyArterial Calcification and Not Lumen Stenosis Is Highly Correlated With Atherosclerotic Plaque Burden in Humans: A Histologic Study of 723 Coronary Artery Segments Using Nondecalcifying Methodology
1,009 Citations1998Giuseppe Sangiorgi, John A. Rumberger +5 more
Coronary calcium quantification is an excellent method of assessing atherosclerotic plaque presence at individual artery sites and the remodeling phenomenon is the likely explanation for the lack of a good predictive value between lumen narrowing and quantification of mural calcification.
CirculationSurvival of medically treated patients in the coronary artery surgery study (CASS) registry.
746 Citations1982Michael B. Mock, Ivar Ringqvist +11 more
CirculationLong-term survival of medically treated patients in the Coronary Artery Surgery Study (CASS) Registry.
556 Citations1994Mary J. Emond, Michael B. Mock +7 more
High myocardial jeopardy, high anginal class, and two or three proximal diseased vessels characterize the profile of patients most likely to have received surgical treatment during follow-up.
Schaum's Outline of Theory and Problems of Statistics
483 Citations1972Murray R. Spiegel
This "Schaum's Study Guide" is the perfect tool for getting a handle on statistics, fully stocked with solved problems 508 of them and shows you how to work problems that may not have been fully explained in class.
CirculationRoles of P2-purinoceptors in the cardiovascular system.
473 Citations1991Vera Ralevic, Geoffrey Burnstock
The net effect of ATP and its analogues on isolated vessels or on vascular beds will be the results of actions mediated by P2X- and P2Y-purinoceptor subtypes, although changes in vascular tone and in integrity of nerves and endothelial cells may alter the balance of the response.
Journal of the American College of CardiologyExtent and severity of myocardial hypoperfusion as predictors of prognosis in patients with suspected coronary artery disease
444 Citations1986Marc L. Ladenheim, Brad H. Pollock +5 more
Extent and severity of myocardial hypoperfusion are important independent variables of prognosis in patients with suspected coronary artery disease and a prognostic model was defined that employs extent and severity as stress-dependent orthogonal variables.
New England Journal of MedicineThe Declining Specificity of Exercise Radionuclide Ventriculography
319 Citations1983Alan Rozanski, George Diamond +4 more
Two factors are responsible for the temporal decline in specificity: a change in the population being tested (pretest referral bias) and a preferential selection of patients with a positive test response for coronary angiography (post-test referral bias).
CirculationVulnerable Plaque
277 Citations1996Jessica M. Mann, Michael J. Davies
Two major determinants of plaque vulnerability, core size and cap thickness, are not statistically related and are not related to absolute plaque size or to the degree of stenosis.
RadiologyCoronary artery calcification detected with ultrafast CT as an indication of coronary artery disease.
274 Citations1992Jerome F. Breen, Patrick F. Sheedy +5 more
Ultrafast CT may be beneficial in the screening of selected populations for the presence of atherosclerotic coronary disease and in the detection of patients with angiographically detectable disease.
Catheterization and Cardiovascular DiagnosisReproducibility of coronary arteriographic reading in the coronary artery surgery study (CASS)
270 Citations1982Lloyd D. Fisher, Melvin P. Judkins +12 more
The mean absolute difference between readings of the percent stenosis decreased over the time of the patient enrollment, 1975 to 1978, and may have resulted from major collaborative efforts made during the course of the study to improve the quality of angiography and to standardize the reading of the cine films.
CirculationNatural History of Ischemic Heart Disease in Relation to Arteriographic Findings
263 Citations1974J. O’Neal Humphries, Lewis H. Kuller +3 more
The severity of the atherosclerotic disease of the coronary arteries is demonstrated to be an important predictor of survival in a group of 224 patients followed from 5 to 12 years after coronary arteriography.
Journal of the American College of CardiologyElectron Beam Computed Tomographic Coronary Calcium Score Cutpoints and Severity of Associated Angiographic Lumen Stenosis
249 Citations1997John A. Rumberger, Patrick F. Sheedy +2 more
These data define the ranges for EBCT coronary calcium score cutpoints that predict the likely severity of associated maximal angiographic stenosis severity to a high sensitivity, high specificity or optimal sensitivity/specificity.
CirculationCoronary Calcium, as Determined by Electron Beam Computed Tomography, and Coronary Disease on Arteriogram
243 Citations1995John A. Rumberger, Patrick F. Sheedy +2 more
In a middle-aged population, noninvasive definition of coronary calcium by EBCT has similar predictive value for arteriographic coronary artery disease in men and women.
The American Journal of CardiologyRelation of coronary calcium determined by electron beam computed tomography and lumen narrowing determined by autopsy
216 Citations1994John A. Rumberger, Robert S. Schwartz +4 more
Coronary calcium determined by electron beam computed tomography has the potential to predict segmental histopathologic coronary disease.
JAMAIdentifying Adults at Increased Risk of Coronary Disease
210 Citations1995Steven A. Grover
The ratio of total plasma cholesterol level to high-density lipoprotein cholesterol level is as accurate as current American screening guidelines, and future guidelines should better incorporate high- density cholesterol levels and nonlipid risk factors to target high-risk individuals accurately.
CirculationEffect of Cigarette Smoking on Outcome After Thrombolytic Therapy for Myocardial Infarction
205 Citations1995Cindy L. Grines, Eric J. Topol +7 more
It is hypothesized that the coronary occlusion responsible for infarction may be primarily thrombotic, with improved outcome relating to enhanced patency or the absence of a residual stenosis after thrombolytic therapy.
CirculationClinical course of patients with normal or slightly or moderately abnormal coronary arteriograms: 10-year follow-up of 521 patients.
194 Citations1980W. L. Proudfit, V G Bruschke +1 more
The clinical course was followed for 10 years in 521 patients whose coronary arteriograms did not show any severe obstruction, and the difference in death rates between the normal or mildly diseased groups and the group that had moderate narrowing was significant.
International Journal of Heat and Mass TransferTheory and problems of heat transfer, (schaum's outline series)
183 Citations1979R.D. Gibson
The American Journal of CardiologyNoninvasive identification of severe coronary artery disease using exercise tomographic thallium-201 imaging
166 Citations1992Timothy F. Christian, Todd D. Miller +2 more
Clinical and exercise parameters provide important independent information in the identification of left main or 3-vessel CAD by exercise thallium-201 tomographic imaging, because thallia scintigraphy alone is suggestive of extensive CAD in few patients.
Journal of the American College of CardiologyMeasurements of coronary blood flow and degree of stenosis: Current clinical implications and continuing uncertainties
155 Citations1983Francis J. Klocke
Journal of the American College of CardiologyNoninvasive prediction of coronary atherosclerosis by quantification of coronary artery calcification using electron beam computed tomography: Comparison with electrocardiographic and thallium exercise stress test results
124 Citations1995Kouji Kajinami, Hiroyasu Seki +2 more
Quantification of coronary artery calcification with electron beam computed tomography noninvasively predicted angiographically confirmed coronary stenosis was at least as useful and potentially better in some patient groups than those obtained with thallium and ECG exercise testing.
CirculationFifteen year survival study of patients with obstructive coronary artery disease.
117 Citations1983W J Proudfit, Albert V.G. Bruschke +3 more
Survival rates were determined for a group of 598 patients in whom severe coronary disease was demonstrated by arteriography and a simple prognostic stratification was devised that used only ECGs and duration of symptoms for each subset based on the number of arteries affected.
Arteriosclerosis An Official Journal of the American Heart Association IncFactors affecting the extent and severity of coronary artery disease in patients enrolled in the coronary artery surgery study.
102 Citations1982Ronald E. Vlietstra, Richard A. Kronmal +4 more
The results suggest that the risk factors for presence of disease may differ from those influencing angiographic extent and severity, and no positive correlation occurred between the arteriographic measures of disease and the cigarette smoking history.
Mayo Clinic ProceedingsQuantity of Coronary Artery Calcium Detected by Electron Beam Computed Tomography in Asymptomatic Subjects and Angiographically Studied Patients
65 Citations1995Rachel B. Kaufmann, Patrick F. Sheedy +5 more
Subjects with large amounts of CAC but without known CAD risk factors may be a valuable subset of the population to investigate for previously unidentified CAD risk Factors.
CirculationEvidence of Multifocal Activity of Coronary Disease in Patients With Acute Myocardial Infarction
60 Citations1997Maurizio D. Guazzi, Maurizio Bussotti +5 more
The hypothesis that infarction is a hallmark of systemic coronary disease activity and changes might vary according to the "maturation" stage of an atheroma, and maximal expression would be at the level of the offending plaque.
CirculationLipid Lowering Versus Revascularization
46 Citations1997James S. Forrester, Prediman K. Shah
It might be postulate that lipid lowering is the more effective therapy for both prevention of acute myocardial infarction and long-term survival.
The American Journal of CardiologyCoronary Anatomic and Procedural Characteristics of Patients Randomized to Coronary Angioplasty in the Bypass Angioplasty Revascularization Investigation (BARI)
26 Citations1995David O. Williams
The purpose of this report is to describe the coronary anatomic characteristics of the 915 patients assigned to the angioplasty arm of the BARI trial and the manner in which angiopLasty was performed.
The American Journal of CardiologySmokers Undergoing Percutaneous Coronary Revascularization Present With Fewer Narrowings in the Target Coronary Artery
19 Citations1997David Hasdai, Charanjit S. Rihal +3 more
Among patients undergoing percutaneous coronary revascularization, cigarette smoking remained associated with fewer lesions in the target artery even after adjusting for age, extent of coronary artery disease, diabetes mellitus, and hypertension.
The American Journal of CardiologyPrognosis with abnormal thallium images in the absence of significant coronary artery disease
16 Citations1992Charles R. Cannan, Todd D. Miller +3 more
Patients with abnormal thallium images in the absence of significant CAD have an excellent short-term prognosis, and three-year survival without myocardial infarction or revascularization was 97%.
Journal of the American College of Cardiology800-1 Total Coronary Calcified Volume is Highly Correlated with Total Plaque Volume: A Histologic Study of 723 Segments
7 Citations1995Giuseppe Sangiorgi, Sanjay S. Srivatsa +6 more
The total plaque area of all segments appears to be accurately estimated by calcific area, suggesting that calcification by UFCT may be used to determine total plaque volume in the coronary trees of living patients.