Longitudinal course of panic disorder: Clinical and biological considerations
Progress in Neuro-Psychopharmacology and Biological PsychiatryPublished 1 January 1985
Thomas W. Uhde, Jean‐Philippe Boulenger, Peter Roy‐Byrne, Marilla Geraci, Bernard J. Vittone, Robert M. Post
Citations200
SJR quartileQ1
SJR score1.77
SNIP1.37
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The longitudinal course of panic disorder and its associated symptoms were investigated in patients and the temporal relationships among panic attacks, generalized anxiety, agoraphobia and depression are described.
Abstract
The longitudinal course of panic disorder and its associated symptoms were investigated in thirty-eight patients. The temporal relationships among panic attacks, generalized anxiety, agoraphobia and depression are described. Similar and different biological alterations in the tricyclic-responsive disorders of primary depression and panic disorder are reviewed and discussed.
Keywords
Psychology
Life SciencesII. New evidence for a locus coeruleus-norepinephrine connection with anxiety
666 Citations1979D. Eugene Redmond, Y.H. Huang
Data from studies of the function of the nucleus locus coereleus in non-human primates are presented in the context of recent anatomical, physiological, pharmacological, and animal behavioral experiments, suggesting implications for the treatment of anxiety, drug addictions, pain, and psychosomatic diseases.
New England Journal of MedicineLactate Metabolism in Anxiety Neurosis
651 Citations1967Ferris N. Pitts, James N. McClure
The rise in blood lactate per units of work output per unit of time in the anxiety neurotics approximates that of patients with arteriosclerotic heart disease.
American Journal of PsychiatryPSYCHIATRIC REACTION PATTERNS TO IMIPRAMINE
418 Citations1962Donald F. Klein, Max Fink
Imipramine was favorably evaluated in 79% of subjects with affective disorders and 51% of schizophrenic patients and the use of psychiatric reaction patterns to psychotropic drugs for categorizing patients and providing a basis for a more rational pharmacotherapy are emphasized.
Archives of General PsychiatryLife Events and Depressive Disorder Reviewed
395 Citations1980Camille Lloyd
It is suggested that stressful events can bring about depressive episodes, but most of the evidence that supports this conclusion emanates from retrospective studies, and corroborating prospective studies are definitely needed.
Archives of General PsychiatryPanic Disorder and Major Depression
369 Citations1983James F. Leckman
Major depression plus panic disorder in probands was associated with a marked increase in risk in relatives for a number of psychiatric disorders; relatives were more than twice as likely to have major depression, panic disorder, phobia, and/or alcoholism than the relatives of probands with major depression without any anxiety disorder.
Life SciencesYohimbine induced anxiety and increased noradrenergic function in humans: Effects of diazepam and clonidine
349 Citations1983Dennis S. Charney, George R. Heninger +1 more
Findings indicate that noradrenergic hyperactivity may be a factor in the production of some anxiety states and the anti-anxiety effects of clonidine appear to result from its actions on receptors which decrease nor adrenergic activity.
Psychological MedicineLife-events and psychiatric disorders Part 1: some methodological issues
343 Citations1973George W. Brown, F. Sklair +2 more
Archives of General PsychiatryTreatment of Phobias
342 Citations1983Charlotte M. Zitrin
Although the conditions of most patients in each group showed moderate to marked improvement, the effects of imipramine were significantly superior to those of placebo in patients with spontaneous panic attacks, ie, patients with agoraphobia or mixed phobia.
American Journal of PsychiatryFrom metapsychology to molecular biology: explorations into the nature of anxiety
261 Citations1983Eric R. Kandel
Findings suggest that a surprisingly simple set of cellular and molecular mechanisms in various combinations may underlie a wide range of both adaptive and maladaptive behavioral modifications.
Archives of General PsychiatryBehavior Therapy, Supportive Psychotherapy, Imipramine, and Phobias
246 Citations1978Charlotte M. Zitrin
In agoraphobics and mixed phobics (both groups experiencing spontaneous panic attacks), imipramine was significantly superior to placebo, and there was no difference between behavior therapy and supportive therapy, both resulting in high improvement rates.
Archives of General PsychiatryEffects of Clonidine on Anxiety Disorders
226 Citations1981Rudolf Hoehn‐Saric
The main effect of clonidine was a decrease of anxiety attacks and "psychic" symptoms, which may indicate disturbances in other neurotransmitter systems that are not affected byClonidine.
Psychological MedicineA study of agoraphobic housewives
195 Citations1977Dorothy Buglass, John Clarke +3 more
Two groups of married agoraphobic women referred to out-patient clinics in Edinburgh were compared and on most measures of attitudes, behaviour, domestic organization and marital interaction, the 2 groups were strikingly similar.
Archives of General PsychiatryIncreased Sensitivity to Caffeine in Patients With Panic Disorders
193 Citations1984Jean‐Philippe Boulenger
The results of a caffeine consumption inventory indicated that patients with panic anxiety disorder, but not affectively ill patients or normal controls, had levels of self-rated anxiety and depression that correlated with their degree of caffeine consumption, and suggested that Patients with panic disorder had an increased sensitivity to the effects of one cup of coffee.
Psychiatry ResearchGrowth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls
190 Citations1982Larry J. Siever, Thomas W. Uhde +5 more
The diminished GH response to clonidine observed suggests that many depressed patients may have decreased alpha-adrenoreceptor responsiveness, and this model might have implications for understanding the functional status of the noradrenergic neurotransmitter system in depressed patients and the possible subtyping of affective disorder patients.
PubMedNew studies and perspectives on the noradrenergic receptor system in depression: effects of the alpha 2-adrenergic agonist clonidine.
157 Citations1984L.J. Siever, Thomas W. Uhde
Results suggest that diminished alpha 2-adrenergic responsiveness as documented by decreased endocrine, biochemical, and physiological responses to clonidine may be related to the depressive and anxiety symptoms as well as the neuroendocrine disturbances characteristic of many depressed patients.
Brain ResearchEndogenous opiods may mediate post-ictal behavioral depression in amygdaloid-kindled rats
156 Citations1979Hanan Frenk, Jerome Engel +3 more
The British Journal of PsychiatryAnxiety and the Effects of Sodium Lactate Assessed Clinically and Physiologically
154 Citations1971Desmond Kelly, Nita Mitchell-Heggs +1 more
There may be something highly specific about lactate ion in producing the naturally occurring hypocalcaemic anxiety symptoms in human beings.
American Journal of PsychiatryAnxiety disorders and depression: contradictions between family study data and DSM-III conventions
143 Citations1983J F Leckman, Kathleen R. Merikangas +3 more
The findings indicate that relatives of individuals with major depression plus an anxiety disorder are at greater risk for major depression, as well as anxiety disorders; than are the relatives of Individuals withMajor depression without an anxiety Disorder.
Archives of General PsychiatryAffective Disorder and Alcoholism in Families of Agoraphobics
135 Citations1981Dennis J. Munjack
The increased incidence of affective disorder in first-degree relatives distinguishes agoraphobia from other phobic disorders.
Archives of Neurology And PsychiatryMental Symptoms in Temporal Lobe Epilepsy and Temporal Lobe Gliomas.
123 Citations1959Stanley Cobb
A clear and well-thought-out monograph on temporal lobe epilepsy, giving an excellent historical background of the authors' knowledge of the temporal lobe, paying due respect to Hughlings Jackson and the other great figures in early English neurology.
Comprehensive PsychiatrySecondary depression in anxiety disorders
107 Citations1981Robert S. Dealy, Dean Ishiki +3 more
The Canadian Journal of PsychiatryThe Relationship between Agoraphobia and Primary Affective Disorders
105 Citations1979Rudy Bowen, Jiřı́ Kohout
The British Journal of PsychiatryGrowth Hormone Response to Clonidine in Obsessive-Compulsive Patients
90 Citations1983Larry J. Siever, Thomas R. Insel +5 more
These results support other observations of a psychobiologic affinity between these two groups and are also compatible with an association between increased presynaptic noradrenergic activity and decreased post-synaptic receptor responsiveness.
Journal of Clinical PsychopharmacologyLack of Efficacy of a New Antidepressant (Bupropion) in the Treatment of Panic Disorder with Phobias
85 Citations1983David V. Sheehan, Jonathan Davidson +2 more
Comprehensive PsychiatryTemporal lobe epilepsy and the phobic anxiety-depersonalization syndrome. Part II: Practical and theoretical considerations
82 Citations1962Martin Roth, Max Harper
Archives of General PsychiatryAgoraphobic Syndrome (Phobic Anxiety State)
82 Citations1970Isaac Marks
The agoraphobic syndrome is the commonest and most distressing phobic disorder met with in adult patients, and itsiology and treatment will only be alluded to briefly, and have been reviewed in detail elsewhere in the book Fear and Phobias.
Psychiatry ResearchPlatelet 3H-imipramine binding in euthymic bipolar patients
68 Citations1982Wade H. Berrettini, John I. Nürnberger +2 more
No differences between these two groups were found in beta max or binding affinity (Kd), which suggests that 3H-imipramine binding to platelets is not a state-independent marker for affective illness.
Archives of NeurologyFear Responses in Patients With Epilepsy
60 Citations1982Eva von Strauss, Anthony H Risser +1 more
Differences between right and left temporal lobe epileptics, but also between these groups and those with and without other CNS dysfunction are demonstrated.
European Journal of PharmacologyAn in vitro binding assay which differentiates benzodiazepine ‘agonists’ and ‘antagonists’
55 Citations1982Phil Skolnick, Margaret M. Schweri +3 more
An in vitro test which discriminates benzodiazepine "agonists' and 'antagonists' has been developed by exploiting the apparent differences in modulation of the benzidiazepine receptor by these classes of compounds.
Psychiatry ResearchClonidine suppresses the opioid abstinence syndrome without clonidine-withdrawal symptoms: A blind inpatient study
51 Citations1980Thomas W. Uhde, D. Eugene Redmond +1 more
Clonidine-treated patients had significantly fewer symptoms than a comparable group of opioid addicts abruptly withdrawn from methadone and no exacerbation of symptomatology developed after the cessation of clonidine.
EpilepsiaStatus Epilepticus Partialis with Fear as Clinical Expression Report of a Case and Ictal EEG Findings
47 Citations1973Georg F. Henriksen
The patient presented here seems to be the first whose EEG was recorded during pure fear‐seizures, and it is believed that this patient has never been presented with fear as an epileptic symptom.
Neuropharmacology[3H]-Imipramine binding in human platelets: A new biochemical parameter in depression
39 Citations1980Michael S. Briley, Rita Raisman +3 more
The Journal of Nervous and Mental DiseasePanic Attacks
35 Citations1981Leon Grunhaus, Sergio Gloger +1 more
The results of the controlled pharmacological trials on patients complaining of panic attacks are presented and some relationships between panic attacks, panic disorder, and agoraphobia are discussed.
Brain ResearchEndorphin mediation of post-ictal effects of kindled seizures in rats
33 Citations1982John E. Kelsey, James D. Belluzzi
Endorphin-released during seizures do not appear to mediate the production of kindled seizures, but do appear to Mediate the transient posts ictal inhibition of seizures.
American Journal of PsychiatryResponse of panic disorder and resistance of depression to imipramine
26 Citations1982H. George Nurnberg, Emil F. Coccaro
The authors present the cases of two patients with panic disorder and major depression whose panic responded to imipramine but whose depression did not.
Aviation Space and Environmental MedicineComplex Partial Seizures
24 Citations2007Kathleen W. Jones
A case of complex partial seizure disorder is reported in an airline transport pilot, along with a discussion of the seizure disorder and its aeromedical implications.
Human Anxiety and Noradrenergic Function: Preliminary Studies with Caffeine, Clonidine and Yohimbine
16 Citations1985Thomas W. Uhde, J.-P. Boulenger +3 more
It is demonstrated that electrical and pharmacological activation of the noradrenergic nucleus locus coeruleus in the monkey produced fear behaviors similar to those occurring during exposure to natural threat in the wild.
Carbamazepine: Treatment of Affective Illness and Anxiety Syndromes
5 Citations1985Thomas W. Uhde, Naresh P. Emmanuel +1 more