6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Côte d'Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial
The LancetPublished 1 March 1999
François Dabis, Philippe Msellati, Nicolas Méda, Christiane Welffens-Ekra, Bruno You, Olivier Manigart
Citations508
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
A short course of oral zidovudine given during the peripartum period is well accepted and well tolerated, and provides a 38% reduction in early vertical transmission of HIV-1 infection despite breastfeeding.
Abstract
A short course of oral zidovudine given during the peripartum period is well accepted and well tolerated, and provides a 38% reduction in early vertical transmission of HIV-1 infection despite breastfeeding.
Keywords
Medicine
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A short course of twice-daily oral zidovudine was safe and well tolerated and, in the absence of breastfeeding, can lessen the risk for mother-to-child HIV-1 transmission by half.
The LancetShort-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire: a randomised trial
550 Citations1999Stefan Z. Wiktor, Ehounou Ekpini +9 more
Short-course oral zidovudine was safe, well tolerated, and decreased mother-to-child transmission of HIV-1 at age 3 months, and substantial efforts will be needed to ensure successful widespread implementation of such a regimen.
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361 Citations1991Philippe Van de Perre, Arlette Simonon +10 more
A prospective cohort study in Kigali, Rwanda, of 212 mother—infant pairs who were seronegative for HIV-1 at delivery and after a mean follow-up of 16.6 months, 16 of the 212 mothers became seropositive for HIV in their infants, and one infant was excluded from the analysis because of a positive test on the blood sample obtained at birth.
Journal of Acquired Immune Deficiency Syndromes & Human RetrovirologyRates of Mother-to-Child Transmission of HIV-1 in Africa, America, and Europe
294 Citations1995&NA;
With use of a standardized methodology, the overall TR of HIV-1 tends to be higher in Africa than in Europe or the U.S.A.
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264 Citations1998Valériane Leroy, Marie‐Louise Newell +8 more
Risk of late postnatal transmission is consistently shown to be substantial for breastfed children born to HIV-1-positive mothers, and should be balanced against the effect of early weaning on infant mortality and morbidity and maternal fertility.
JAMAProspective Comparison of Mother-to-Child Transmission of HIV-1 and HIV-2 in Abidjan, Ivory Coast
214 Citations1994Georgette Adjorlolo-Johnson
The rate of perinatal transmission of HIV-2 was much lower than the rate ofPerinatal transmitted HIV-1, and this was associated with more favorable survival for infants ofAIDS-2-infected mothers, and public health guidelines should incorporate advice that perinnatal transmission of AIDS-2 is rare.
The Journal of Infectious DiseasesEstimating the Timing of Mother-to-Child Transmission of Human Immunodeficiency Virus in a Breast-Feeding Population in Kinshasa, Zaire
194 Citations1996Jeanne Bertolli, Michael E. St. Louis +7 more
The results support earlier studies indicating that most transmission occurs during labor and delivery or in the early postpartum period and that the risk of HIV transmission through breast-feeding during the post partum period is substantial.
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165 Citations1997Ehounou Ekpini, Stefan Z. Wiktor +10 more
Breastfed children born to mothers seropositive for HIV-1 alone or seroreactive to both HIV- 1 and HIV-2 in Abidjan are at substantial risk of late postnatal transmission of HIV, and early cessation of breastfeeding at 6 months of age should be assessed as a possible intervention to reduce postnatal Transmission of HIV.
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164 Citations1998Rhoda Sperling, David E. Shapiro +12 more
There were no identified problems that would alter current recommendations for the routine use of ZDV for the prevention of mother–child HIV-1 transmission and there was no serious pattern of adverse pregnancy outcomes associated withZDV use.
AIDSImpact of zidovudine use on risk and risk factors for perinatal transmission of HIV
132 Citations1998R. J. Simonds, Richard W. Steketee +11 more
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AIDSEstimating the rate of mother-to-child transmission of HIV. Report of a workshop on methodological issues Ghent (Belgium), 17–20 February 1992
130 Citations1993François Dabis, Philippe Msellati +5 more
A common methodology was developed and can now be applied to all studies with sufficient follow-up and comparisons made between transmission rates, essential for assessing determinants of transmission and for the development of a common approach for the evaluation of interventions aimed at reducing or interrupting MTCT of HIV.
The Journal of PediatricsAcceptability and impact of zidovudine for prevention of mother-to-child human immunodeficiency virus–1 transmission in France
125 Citations1997Marie‐Jeanne Mayaux, J.P. Teglas +10 more
Zidovudine prevention is now widely used in France and has had a major impact on the epidemiology of mother-child human immunodeficiency virus transmission, which justifies a policy of offering human immunosuppression virus screening to all women before or shortly after the diagnosis of pregnancy.
PubMedAn assessment of the timing of mother-to-child transmission of human immunodeficiency virus type 1 by means of polymerase chain reaction.
93 Citations1994Arlette Simonon, Philippe Lepage +8 more
Blood was collected at birth, at 3, 6-12, and 13-24 months in 218 children born to HIV-1-seropositive mothers in Kigali, Rwanda to approximate the contributions of in utero, intrapartum, and postnatal transmission of human immunodeficiency virus type-1 and to evaluate polymerase chain reaction (PCR) as a diagnostic tool for pediatric HIV infection.
JAMAAdministration of Zidovudine During Late Pregnancy and Delivery to Prevent Perinatal HIV Transmission—Thailand, 1996-1998
85 Citations1998
The ZDV regimen used in this study is more feasible for implementation in developing country settings than the one currently used in the US (associated with a 66% reduction in HIV transmission): it costs US$50 starts later in pregnancy involves less frequent dosing and oral dosing during labor and does not involve infant treatment.
AIDSAttitude of pregnant women towards HIV testing in Abidjan, Côte dʼIvoire and Bobo-Dioulasso, Burkina Faso
81 Citations1998Michel Cartoux, Philippe Msellati +6 more
In the two sites, the counsellors themselves and high educational level of the women appeared to be related to refusal of the test, whereas last trimester gestation was associated with failure to return for test results.
AIDSPrevention of mother-to-child transmission of HIV-1 infection
58 Citations1998Julie Ratcliffe, A. E. Ades +3 more
Considering the estimated cost of caring for an infected child, ZDV appears to be cost-effective under any of the circumstances examined, however, elective CS may not becost-effective in populations where the uptake of ZDv is high, and a more precise estimate of its efficacy is required.
American Journal of Obstetrics and GynecologyPostnatal transmission of human immunodeficiency virus type 1: The breast-feeding dilemma
50 Citations1995Philippe Van de Perre
According to the current knowledge the World Health Organization and the United Nations Children's Fund reasonably recommend continuing breast-feeding promotion in women living in settings where infectious diseases and malnutrition are the primary causes of infant deaths such as in many developing countries.
Infectious Diseases in Clinical PracticeAdministration of Zidovudine During Late Pregnancy and Delivery to Prevent Perinatal HIV Transmission—Thailand, 1996–1998
50 Citations1998Beverly E. Sha
Preliminary trial results indicate that a short-term antenatal regimen of ZDV reduced the risk for perinatal HIV transmission by approximately half.
AIDSCost-effectiveness and cost-benefit in the prevention of mother-to-child transmission of HIV in developing countries
40 Citations1998Marie‐Louise Newell, François Dabis +2 more
AIDSPrevention of mother-to-child transmission of HIV in Africa
38 Citations1998Philippe Msellati, R. Ramón +5 more
The finding that it was necessary to perform HIV tests in 1824 women to recruit 71 women for a clinical trial of ZDV indicates a need for IEC campaigns aimed at women of childbearing age about maternal-child HIV transmission and its prevention.
BJOG An International Journal of Obstetrics & GynaecologyTherapeutic and other interventions to reduce the risk of mother‐to‐child transmission of HIV‐1 in Europe
38 Citations1998The European Collaborative Study
Policy policies regarding the use of interventions to reduce risk of vertical transmission of human immunodeficiency virus (HIV) and the extent of changes since 1994 are documented.
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The prevalence of syphilis among pregnant women in Burkina Faso is relatively low compared with that of HIV infection and the need for HIV surveillance in this sentinel population is urgent to follow the course of the epidemic and to measure the impact of interventions.
Médecine et Maladies InfectieusesSéroprévalence de l'infection par le VIH dans les consultations prénatales d'Abidjan, Côte d'Ivoire, 1995
16 Citations1997Fatoumata Sylla‐Koko, Xavier Anglaret +5 more
A sample of adult pregnant women was studied from April to June 1995, in five antenatal clinics located in Abidjan, Cote d'Ivoire, where 194 women were HIV+ and women were considered as HIV-infected (HIV+) when the two tests were positive.
PubMedZidovudine to decrease mother-to-child transmission of HIV-1: is it good for developing countries?
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American Journal of Public HealthThe prevention of perinatal HIV transmission in the less-developed world.
13 Citations1998Mervyn Susser
This editorial refers to a set of articles that address the controversy surrounding prophylactic trials in developing countries to avert maternal-infant transmission of HIV by establishing alternatives to the standard but costly US regimen, which led to the premature end of a trial in Thailand.
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9 Citations1996Michel Cartoux, Philippe Msellati +7 more
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ScienceControversial Trial Offers Hopeful Result
2 Citations1998Eliot Marshall
A US-funded placebo-controlled clinical trial in Thailand has found that a brief relatively inexpensive course of the antiretroviral drug AZT given during the final weeks of pregnancy can reduce the transmission of HIV from mothers to their newborn infants.