Association of Genetic Risks for Schizophrenia and Bipolar DisorderWith Specific and Generic Brain Structural Endophenotypes
Archives of General PsychiatryPublished 1 October 2004
Colm McDonald, Edward T. Bullmore, Pak C. Sham, Xavier Chitnis, Harvey Wickham, Elvira Bramon
Citations375
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TL;DR
Investigating the relationship between genetic risk and structural variation throughout the entire brain in patients and their unaffected relatives sampled from multiply affected families with schizophrenia or bipolar disorder found the 2 major psychoses show both distinctive and similar patterns of brain structural abnormality related to variable genetic risk.
Abstract
Genetic risks for schizophrenia and bipolar disorder are associated with specific gray matter but generic white matter endophenotypes. Thus, Emil Kraepelin's pivotal distinction was neither wholly right nor wholly wrong: the 2 major psychoses show both distinctive and similar patterns of brain structural abnormality related to variable genetic risk.
Keywords
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