brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2
CellPublished 1 February 1992
John W. Tamkun, Renate Deuring, Matthew P. Scott, Mark Kissinger, Angela Pattatucci, Thomas C. Kaufman
Citations963
SJR quartileQ1
SJR score22.61
SNIP7.62
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TL;DR
The brahma (brm) gene encodes a 1638 residue protein that is similar to SNF2/SWI2, a protein involved in transcriptional activation in yeast, suggesting possible models for the role of brm in the transcriptionalactivation of homeotic genes.
Abstract
The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila. Loss-of-function brm mutations suppress mutations in Polycomb, a repressor of homeotic genes, and cause developmental defects similar to those arising from insufficient expression of the homeotic genes of the Antennapedia and Bithorax complexes. The brm gene encodes a 1638 residue protein that is similar to SNF2/SWI2, a protein involved in transcriptional activation in yeast, suggesting possible models for the role of brm in the transcriptional activation of homeotic genes. In addition, both brm and SNF2 contain a 77 amino acid motif that is found in other Drosophila, yeast, and human regulatory proteins and may be characteristic of a new family of regulatory proteins.
Keywords
Agricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
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