Positron emission tomographic studies in restless legs syndrome
Movement DisordersPublished 1 January 1999
Claudia Trenkwalder, Arthur S. Walters, Wayne A. Hening, Sudhansu Chokroverty, Angelo Antonini, Vijay Dhawan
Citations161
SJR quartileQ1
SJR score2.99
SNIP1.98
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TL;DR
Any abnormal resting brain metabolic activity or putative presynaptic dopaminergic defect in RLS is likely either to be so subtle that it is below the threshold for ready detection by PET or to be located in an area of neural tissue inaccessible to the current scanner.
Abstract
We studied six restless legs syndrome (RLS) patients with [F18]fluorodeoxyglucose (FDG) positron emission tomography (PET). We also studied four of these same patients with [F18]fluorodopa (FDOPA) PET. The patients' FDG and FDOPA PET scans were compared with those from age-matched healthy control subjects. No significant differences between the two groups were found for any regional blood flow values derived from the FDG scans or for any binding constants derived from the FDOPA scans. These results suggest that any abnormal resting brain metabolic activity or putative presynaptic dopaminergic defect in RLS is likely either to be so subtle that it is below the threshold for ready detection by PET or that it is located in an area of neural tissue inaccessible to the current scanner. No substantial defect is likely to involve the dopaminergic nigrostriatal axis.
Keywords
Medicine
Clinical Neurology and NeurosurgeryCo-planar stereotaxic atlas of the human brain
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A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
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General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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Jaypee Brothers Medical Publishers (P) Ltd. eBooksParkinson’s Disease and Movement Disorders
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The neuropathology of Parkinsonian disorders clinical rating scale for tremor rating scales in Parkinson's disease tremors, differential diagnosis and pharmacology different clinical presentations of myoclonous tics dystomic syndromes and the pathophysiology of drug-induced movement disorders drug- induced dyskinesias akathisia and the restless legs syndrome ataxia.
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There are two major etiologic subgroups of RLS but that the two share central pathophysiologic mechanisms, and it is concluded that Levodopa and dopamine agonists were the most effective treatments.
Annals of NeurologyNigrostriatal function in humans studied with positron emission tomography
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The application of a unidirectional transfer model is demonstrated to the analysis of [18F]6‐fluoro‐L‐dopa and positron emission tomography data and provided in vivo confirmation of an age‐related impairment of nigrostriatal function.
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Observations support the hypothesis that RLS and PMS are two manifestations of the same central sensorimotor disorder.
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Human Molecular GeneticsRecessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene
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Pergolide provided a good treatment for the RL syndrome, particularly for the more severe RL cases without significant problems with RL augmentation, and the patients with PLMS respondedbest to carbidopa/levodopa, whereas severe RL patients responded best to pergolides.
Annals of NeurologyDopamine-containing neurons in the spinal cord: Anatomy and some functional aspects
168 Citations1983Olle Lindvall, A. Bj�rklund +1 more
NeurologyEarly differential diagnosis of Parkinson's disease with <sup>18</sup> F‐fluorodeoxyglucose and positron emission tomography
161 Citations1995David Eidelberg, James R. Moeller +8 more
Group assignments into the normal or parkinsonian categories with FDGPET were comparable to those achieved with FDOPA-PET, although APD and EPD patients were not differentiable by the latter method.
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Ten patients with involuntary leg movements due to myelopathy were studied clinically and polysomnographically and it was suggested that PLM of spinal cord origin has a common mechanisms with spinal automatism.
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The hypothesis that RLS and PMS may both result from reduced dopaminergic activity in the CNS, perhaps resulting from decreased sensibility of postsynaptic receptors, is raised.
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PubMedAssessment of disease severity in parkinsonism with fluorine-18-fluorodeoxyglucose and PET.
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Findings indicate that regional metabolic covariance patterns are robust imaging markers of disease severity and may be useful clinically in assessing parkinsonian disability and disease progression.
PubMedA clinical and polysomnographic comparison of neuroleptic-induced akathisia and the idiopathic restless legs syndrome.
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The spinal origin of the involuntary limb movements in patients with RLS is confirmed by the long duration of jerks, the recruitment characteristics, and the periodicity of the jerks.
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In most patients with restless legs syndrome, the results of complete blood cell counts and iron, ferritin, folate, and vitamin B12 levels are normal, and no hematologic or chemical abnormalities have been reported in patients with periodic movements of sleep who do not also have restless legs Syndrome.
JAMAParkinson's Disease and Movement Disorders
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Clinical NeuropharmacologyClinical Presentation and Neuropharmacology of Restless Legs Syndrome
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