Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein
NaturePublished 1 March 1990
Günter Reuter, Marianna Giarrè, Joseph A Farah, János Gausz, Anne Spierer, Pierre Spierer
Citations228
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
This work has shown that the number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers, which could help in packaging the chromatin fibre into heterochromatin.
Abstract
Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.
Keywords
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