Drug-induced sexual dysfunction

An attempt has been made, based on recent advances in sexual physiology, to clarify drug-induced sexual dysfunction on the basis of possible or probable mechanisms of action to allow the physician to rationally select pharmacologic agents which minimize deleterious effects on libido, erection, ejaculation and orgasm.

Abstract

Drug-induced sexual dysfunction is a relatively common yet poorly understood clinical problem. The mechanisms whereby various drug classes alter sexual function remain poorly documented. An attempt has been made, based on recent advances in sexual physiology, to clarify drug-induced sexual dysfunction on the basis of possible or probable mechanisms of action. It is hoped that this approach may ultimately allow the physician to rationally select pharmacologic agents which minimize deleterious effects on libido, erection, ejaculation and orgasm.