HRAS1 Rare Minisatellite Alleles and Breast Cancer in Australian Women Under Age Forty Years
JNCI Journal of the National Cancer InstitutePublished 15 December 1999
F A Firgaira, R. Seshadri, Christopher R. McEvoy, Gillian S. Dite, Graham G. Giles, M.R.E. McCredie
Citations24
SJR quartileQ1
SJR score5.70
SNIP2.66
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
There was no support for an association between rare HRAS1 alleles and the risk of early-onset breast cancer, despite 80% power to detect effects of the magnitude of those associations previously suggested.
Abstract
The question of whether cancer risk is associated with rare minisatellite HRAS1 alleles needs to be revisited with the use of new methods that have a greater ability to distinguish rare alleles from similarly sized common alleles.
Keywords
Biochemistry, Genetics and Molecular Biology
Transactions of the Royal Society of EdinburghXV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
4,448 Citations1919R. A. Fisher
This work attempted to ascertain the biometrical properties of a population of a more general type than has hitherto been examined, inheritance in which follows the Mendelian scheme of inheritance, hoping that in this way it will be possible to make a more exact analysis of the causes of human variability.
The American Journal of Human GeneticsGenetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families
3,047 Citations1998Deborah Ford, Douglas F. Easton +36 more
The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in bRCA2 carriers <50 years of age.
New England Journal of MedicineAn Association between the Risk of Cancer and Mutations in the HRAS1 Minisatellite Locus
288 Citations1993Theodore G. Krontiris, Bernie Devlin +3 more
NatureUnique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients
283 Citations1985Theodore G. Krontiris, Nancy A. DiMartino +2 more
White blood cell DNA from cancer patients and DNA from tumours and tumour-derived cell lines frequently demonstrated allelic restriction fragments of the Harvey ras oncogene locus not found in the unaffected population, which may be linked to susceptibility to cancer.
Cancer Causes & ControlBreast cancer in Australian women under the age of 40
120 Citations1998Margaret R.E. McCredie, Gillian S. Dite +2 more
This study of Australian women has indicated that some risk factors for breast cancer in women under age 40 differ from those reported for older women either in direction (e.g., weight) or relative importance (e-g., family history).
The BreastBackground, rationale and protocol for a case-control-family study of breast cancer
67 Citations1994John L. Hopper, Graham G. Giles +2 more
The aims, rationale and protocol for one population-based study being conducted in Melbourne and Sydney, Australia, which allows the strengths and roles of genetic and environmental risk factors to be studied within an epidemiological setting, has the potential to address the consequences for public health of new molecular genetic findings.
JNCI Journal of the National Cancer InstituteEstrogen Receptor Polymorphism at Codon 325 and Risk of Breast Cancer in Women Before Age Forty
58 Citations1998Melissa C. Southey, Leigh Batten +5 more
PubMedHRAS protooncogene polymorphism and breast cancer.
39 Citations1993Peter A. Garrett, Barbara S. Hulka +2 more
It is concluded that rare HRAS alleles are associated with breast cancer and that this association may be stronger in black women than in white women, and these alleles have the potential to become a valuable screening biomarker for women at increased risk for breast cancer.
PubMedLarge DNA fragment sizing using native acrylamide gels on an automated DNA sequencer and GENESCAN software.
8 Citations1998Christopher R. McEvoy, R. Seshadri +1 more
Investigation of the potential of the PE Applied Biosystems Model 373 Automated DNA Sequencer and GENESCAN software to size minisatellite alleles ranging in size from 230 bp to 2.5 kbp finds variability in size calling increased with larger alleles, in particular when sizes exceeded 2 kbp.