Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

While the PPI model based on the effects of direct DA agonists is the most well-validated for the identification of known antipsychotic drugs, the isolation rearing model also appears to be sensitive to both typical and atypical antipsychotics, and the 5-HT P PI model is less generally sensitive to antippsychotic medications, but can provide insight into the contribution of serotonergic systems to the actions of newer antipsychosis that act upon multiple receptors.

Abstract

Studies of drug effects on PPI in rats have generated four distinctive models that have utility in the identification of antipsychotic medications. Because each of these models has specific advantages and disadvantages, the choice of model to be used depends upon the question being addressed. This review should help to guide such decisions.