Rhodium-Catalyzed Addition of\nArylboronic Acids to Isatins: \nAn Entry to Diversity in\n3-Aryl-3-Hydroxyoxindoles
FigsharePublished 1 March 2016Open access
Patrick Y. Toullec, Richard B. C. Jagt, Johannes G. de Vries, Ben L. Feringa, Adriaan J. Minnaard
Citations152
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Abstract
A general method for the catalytic 1,2-addition of aryl and alkenyl boronic acids to isatins is described using a rhodium(I)/triphenylphosphite\ncatalyst. The application of this transformation allows the synthesis of a variety of 3-aryl-3-hydroxyoxindole building blocks in high yields. An\nenantioselective version of this reaction using a rhodium(I)/phosphoramidite system is also presented.
Keywords
Chemistry
Organic LettersRhodium-Catalyzed Addition of Arylboronic Acids to Isatins: An Entry to Diversity in 3-Aryl-3-Hydroxyoxindoles
188 Citations2006Patrick Y. Toullec, Richard B. C. Jagt +3 more
A general method for the catalytic 1,2-addition of aryl and alkenyl boronic acids to isatins is described using a rhodium(I)/triphenylphosphite catalyst and allows the synthesis of a variety of 3-aryl-3-hydroxyoxindole building blocks in high yields.
FigshareRhodium-Catalyzed Addition of\nArylboronic Acids to Isatins: \nAn Entry to Diversity in\n3-Aryl-3-Hydroxyoxindoles
152 Citations2016Patrick Y. Toullec, Richard B. C. Jagt +3 more