The Binding of Both [3H]Nemonapride and [3H]Raclopride Is Increased in Schizophrenia
Biological PsychiatryPublished 1 October 1997
P. L. Marzella, Christine Hill, Nicholas A Keks, Bruce Singh, David Copolov
Citations30
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
A postmortem autoradiographic study to compare the density of dopamine D4-like sites in caudate putamen section from age-matched schizophrenia and control populations revealed that in the schizophrenia population there was a significant increase in the binding of both [3H]nemonapride and [ 3H]raclopride.
Abstract
We performed a postmortem autoradiographic study to compare the density of dopamine D4-like sites in caudate putamen section from age-matched schizophrenia (n = 15) and control (n = 15) populations. The densities of the D4-like sites were estimated by subtracting the density of [3H]raclopride (binding D2 and D3 receptors) from the density of [3H]nemonapride (binding D2, D3, and D4 receptors). The findings revealed that in the schizophrenia population there was a significant increase in the binding of both [3H]nemonapride (2.3-fold) and [3H]raclopride (1.9-fold). In addition, in the schizophrenia population the density of D4-like sites was increased 2.6-fold.
Keywords
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