Neural Evidence for Enhanced Error Detection in Major Depressive Disorder
American Journal of PsychiatryPublished 1 April 2007
Pearl H. Chiu, Patricia J. Deldin
Citations301
SJR quartileQ1
SJR score5.27
SNIP3.68
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
These data implicate exaggerated early error-detection processes in the etiology and maintenance of major depressive disorder, which may then recruit excessive neural and cognitive resources that manifest as symptoms of depression.
Abstract
These data implicate exaggerated early error-detection processes in the etiology and maintenance of major depressive disorder. Such processes may then recruit excessive neural and cognitive resources that manifest as symptoms of depression.
Keywords
PsychologyNeuroscience
Perception & PsychophysicsEffects of noise letters upon the identification of a target letter in a nonsearch task
7,324 Citations1974Barbara A. Eriksen, Charles W. Eriksen
Journal of Consulting and Clinical PsychologyThe measurement of pessimism: The Hopelessness Scale.
5,392 Citations1974Aaron T. Beck, Arlene Weissman +2 more
A scale designed to quantify hopelessness was administered to several diverse samples of patients to assess its psychometric properties and was found to have a high degree of internal consistency and showed a relatively high correlation with the clinical ratings of hopelessness and other self-administered measures of despair.
Electroencephalography and Clinical NeurophysiologyA new method for off-line removal of ocular artifact
5,093 Citations1983Gabriele Gratton, Michael Coles +1 more
EMCP permits retention of all trials in an ERP experiment, irrespective of ocular artifact, and has the advantage that separate correction factors are computed for blinks and movements and that these factors are based on data from the experimental session itself rather than from a separate calibration session.
Journal of Abnormal PsychologyTripartite model of anxiety and depression: Psychometric evidence and taxonomic implications.
3,625 Citations1991Lee Anna Clark, David Watson
Results suggest that anxiety and depression can be reliably and validly assessed; moreover, although these disorders share a substantial component of general affective distress, they can be differentiated on the basis of factors specific to each syndrome.
ScienceThe Role of the Medial Frontal Cortex in Cognitive Control
3,000 Citations2004K. Richard Ridderinkhof, Markus Ullsperger +2 more
New findings in cognitive neuroscience concerning cortical interactions that subserve the recruitment and implementation of cognitive control are evaluated, suggesting that monitoring-related pMFC activity serves as a signal that engages regulatory processes in the LPFC to implement performance adjustments.
Psychological ScienceA Neural System for Error Detection and Compensation
2,901 Citations1993William J. Gehring, Brian Michael Goss +3 more
Analysis of the human event-related brain potentials (ERPs) accompanying errors provides evidence for a neural process whose activity is specifically associated with monitoring and compensating for erroneous behavior.
Biological PsychiatryThe Mesolimbic Dopamine Reward Circuit in Depression
2,005 Citations2006Eric J. Nestler, William A. Carlezon
It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
Cognitive Psychology and Emotional Disorders
1,876 Citations1988J. Mark G. Williams
The Cognitive Approach to Emotional Disorders examines the role of emotion in the decision-making process and the role that emotion plays in the formation of beliefs.
Biological PsychologyERP components on reaction errors and their functional significance: a tutorial
1,450 Citations2000Michael Falkenstein, Jörg Hoormann +2 more
The results suggest that this is a further error-specific component, which is independent of the Ne, and hence associated with a later aspect of error processing or post-error processing.
Biological PsychiatryNeuroimaging studies of mood disorders
1,309 Citations2000Wayne C. Drevets
Findings implicate interconnected neural circuits in which pathologic patterns of neurotransmission may result in the emotional, motivational, cognitive, and behavioral manifestations of primary and secondary affective disorders.
Journal of Cognitive NeuroscienceThe Timing of Action-Monitoring Processes in the Anterior Cingulate Cortex
1,304 Citations2002Vincent van Veen, Cameron S. Carter
The temporal resolution of high-density event-related potentials (ERPs) in combination with source localization is used to investigate the timing of ACC activity during conflict and error detection and predicted that the same area of the ACC is active prior to high-conflict correct responses and following erroneous responses.
PsychophysiologyError‐related brain potentials are differentially related to awareness of response errors: Evidence from an antisaccade task
1,139 Citations2001Sander Nieuwenhuis, K. Richard Ridderinkhof +3 more
Results from the present experiment are consistent with the view that the Ne and Pe reflect the activity of two separate error monitoring processes, of which only the later process, reflected by the Pe, is associated with conscious error recognition and remedial action.
Annual Review of PsychologyDepression: Perspectives from Affective Neuroscience
1,137 Citations2002Richard J. Davidson, Diego A. Pizzagalli +2 more
A model of the ways in which affect can become disordered in depression is constructed and proposals for the specific types of processing abnormalities that result from dysfunctions in different parts of this circuitry are offered.
Nature NeurosciencePrefrontal–cingulate interactions in action monitoring
916 Citations2000William J. Gehring, Robert T. Knight
The lateral prefrontal cortex seemed to interact with the anterior cingulate cortex in monitoring behavior and in guiding compensatory systems, and it was found that medial frontal cortex activity associated with action monitoring depended on activity in the lateral cortex.
Biological PsychiatryActivity and Connectivity of Brain Mood Regulating Circuit in Depression: A Functional Magnetic Resonance Study
791 Citations2005Amit Anand, Yu Li +7 more
The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic areas is consistent with the hypothesis that decreased cortical regulation of limbics activation in response to negative stimuli may be present in depression.
Current Opinion in PsychiatryEmotional information processing in mood disorders: a review of behavioral and neuroimaging findings
637 Citations2005Jukka Leppänen
The reviewed data show that major depressive disorder involves specific abnormalities in the cognitive and neural processing of emotional information and that these abnormalities may potentially contribute to the vulnerability for negative emotion and onset of depressive episodes.
PsychophysiologyOn the ERN and the significance of errors
614 Citations2005Greg Hajcak, Jason S. Moser +2 more
The error-related negativity (ERN) is an event-related brain potential observed when subjects commit errors and was significantly larger on high-value trials in Experiment 1 and during evaluation in Experiment 2, suggesting the error-detection system is sensitive to the significance of errors.
Journal of PsychophysiologyDissociable Components of Error Processing
603 Citations2005Thérèse J.M. Overbeek, Sander Nieuwenhuis +1 more
Journal of Experimental Psychology GeneralMood, personality, and self-monitoring: Negative affect and emotionality in relation to frontal lobe mechanisms of error monitoring.
531 Citations2000Phan Luu, Paul Collins +1 more
The authors demonstrated that variability in the amplitude of the error-related negativity (ERN) is dependent on mood and personality variables and revealed that affective distress and associated behavioral patterns are closely related with frontal lobe executive functions.
Nature NeuroscienceAnterior cingulate and prefrontal cortex: who's in control?
438 Citations2000Jonathan D. Cohen, Matthew Botvinick +1 more
A sophisticated study of error-related brain potentials in patients with prefrontal lesions addresses how the authors monitor performance and adjust cognitive control based on task demands.
Brain and CognitionError-related psychophysiology and negative affect
418 Citations2004Greg Hajcak, Nicole M. McDonald +1 more
The findings that autonomic measures and affective distress are related to response monitoring are consistent with anterior cingulate cortex function, which is implicated in the regulation of affective, response selection, and autonomic resources.
Archives of General PsychiatryFunctional Neuroanatomical Substrates of Altered Reward Processing in Major Depressive Disorder Revealed by a Dopaminergic Probe
343 Citations2005Lescia K. Tremblay, Claudio A. Naranjo +5 more
Dopamine-related neuroanatomical substrates are involved in altered reward processing in major depressive disorder, shedding light on the neurobiology of the anhedonic symptoms in MDD and suggesting these substrates as future therapeutic targets.
Psychological MedicineNeuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance
302 Citations2003Fionnuala C. Murphy, A. Michael +2 more
The present results suggest that feedback can have different effects in different contexts, and misleading, negative feedback appears to disrupt the performance of depressed patients, whereas negative but accurate feedback does not.
Journal of Clinical and Experimental NeuropsychologyThe Role of Functional Neuroimaging in the Neuropsychology of Depression
272 Citations2001Mario Liotti, Helen S. Mayberg
Evidence strongly implicating the dorsolateral prefrontal cortex, particularly in the right hemisphere, as a key brain structure in emotion/cognition interactions in negative mood states is reviewed, suggesting this neocortical region is a crucial convergence zone.
Progress in Neuro-Psychopharmacology and Biological PsychiatryThe role of the brain reward system in depression
251 Citations2001Claudio A. Naranjo, Lescia K. Tremblay +1 more
A novel approach to study the pathophysiology of MDD is introduced that includes pharmacological probing of BRS pathways together with an elicited and measurable behavioral component (e.g. pleasant effects, increased energy, altered cognition).
Archives of General PsychiatryProbing Brain Reward System Function in Major Depressive Disorder
228 Citations2002Lescia K. Tremblay, Claudio A. Naranjo +3 more
The results suggest the presence of a hypersensitive response is present in the brain reward system of depressed patients, which may reflect a hypofunctional state and may provide a novel pathophysiologic and therapeutic target for future studies.
Human Brain MappingResting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: A 128‐channel EEG study
212 Citations2005Diego A. Pizzagalli, Lauren Peccoralo +2 more
The hypothesized abnormal reactions to error would be associated with dysfunctional rostral ACC activity, a region previously implicated in error detection and evaluation of the emotional significance of events, and these findings provide initial insight into putative mechanisms fostering treatment response.
Journal of Abnormal PsychologyReward fails to alter response bias in depression.
184 Citations1994Jeffrey B. Henriques, Jeanne M. Glowacki +1 more
A signal-detection analysis was used to examine the response biases of dysphoric and nondysphoric female undergraduates during 3 payoff conditions: neutral, reward, and punishment, finding that the dysphoric subjects had a smaller change in bias from the neutral to the reward condition compared with the nondysPhoric group.
Journal of Abnormal PsychologyFrontolimbic Response to Negative Feedback in Clinical Depression.
170 Citations2003Don M. Tucker, Phan Luu +3 more
The authors examine whether clinically depressed subjects would show abnormal sensitivity of frontolimbic networks as they evaluated negative feedback to suggest that moderate depression may sensitize limbic networks to respond strongly to aversive events.
Psychological MedicineAbnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression
169 Citations1998Rebecca Elliott, Barbara J. Sahakian +3 more
The findings suggest that the behavioural response to feedback in depressed patients is associated with an abnormal neural response within the medial caudate and ventromedial orbitofrontal cortex, regions implicated in reward mechanisms.
PsychophysiologyThe effect of erroneous responses on response monitoring in patients with major depressive disorder: A study with event‐related potentials
142 Citations2004Martin Ruchsow, Bärbel Herrnberger +4 more
Compared to controls, patients with major depressive disorder showed a less negative ERN/Ne in error trials following error trials, which might reflect impaired response monitoring processes in major depressive Disorder resulting from an underactivity in a central reward pathway and/or a deficit in strategic reasoning.
Journal of Psychiatric ResearchError processing in major depressive disorder: Evidence from event-related potentials
118 Citations2005Martin Ruchsow, Bärbel Herrnberger +4 more
Patients with major depressive disorder again showed a less negative ERN/Ne amplitude in error trials following error trials, which might reflect impaired response monitoring processes in major depressive Disorder resulting from an impaired activation of a central reward pathway and/or a deficit in strategic reasoning.
Personality and Individual DifferencesIntegrative views of motivation, cognition and emotion
76 Citations1995Philip J. Corr
Biological PsychiatryPerformance feedback deficit in geriatric depression
71 Citations2001David C. Steffens, Henry R. Wagner +3 more
Previous findings suggesting a performance feedback deficit in geriatric depression are extended, and the findings support previous studies linking the orbital frontal cortex and depression.
American Journal of PsychiatryA Preliminary Study of Left Frontal Region Error Negativity and Symptom Improvement in Geriatric Depression
38 Citations2003Balu Kalayam, George S. Alexopoulos
Increased left frontal error negative waves are associated with limited or slow change in depressive symptoms in elders receiving citalopram.