Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy.

In comorbid diabetes mellitus and depression, most evidence supports the use of fluoxetine in control of glucose handling and other characteristics in terms dosing, drug interactions, cognition, and sleep make sertraline an attractive alternative agent.

Abstract

In comorbid diabetes mellitus and depression, most evidence supports the use of fluoxetine in control of glucose handling. Other characteristics in terms dosing, drug interactions, cognition, and sleep make sertraline an attractive alternative agent. In diabetic neuropathy without depression, the best choices among non-TCAs may include sertraline, citalopram, and perhaps, venlafaxine, since the TCAs appear to increase cravings and increase FBG levels.