Memory traces unbound
Trends in NeurosciencesPublished 1 February 2003
Karim Nader
Citations743
SJR quartileQ1
SJR score4.73
SNIP3.68
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TL;DR
The hypothesis that reactivation of a consolidated memory can return it to a labile, sensitive state - in which it can be modified, strengthened, changed or even erased is revisited.
Abstract
The idea that new memories are initially 'labile' and sensitive to disruption before becoming permanently stored in the wiring of the brain has been dogma for >100 years. Recently, we have revisited the hypothesis that reactivation of a consolidated memory can return it to a labile, sensitive state - in which it can be modified, strengthened, changed or even erased! The data generated from some of the best-described paradigms in memory research, in conjunction with powerful neurobiological technologies, have provided striking support for a very dynamic neurobiological basis of memory, which is beginning to overturn the old dogma.
Keywords
Neuroscience
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