The role of epidermal growth factor in normal and neoplastic growth of mouse mammary epithelial cells
Cancer treatment and researchPublished 1 January 1988
Takami Oka, Osamu Tsutsumi, Hirohisa Kurachi, Shigeru Okamoto
Citations22
SJR quartileQ4
SJR score0.13
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TL;DR
Epidermal growth factor was discovered by Cohen in 1962 as the principal in extracts of male mouse submandibular gland which produced acceleration of incisor eruption and eyelid opening when administered to newborn mice.
Abstract
Epidermal growth factor (EGF) was discovered by Cohen in 1962 [1] as the principal in extracts of male mouse submandibular gland which produced acceleration of incisor eruption and eyelid opening when administered to newborn mice. It has since been purified to homogeneity and sequenced [2]. Mouse EGF is a single-chain polypeptide (mol. wt. 6045) containing 53 amino acid residues and 3 disulfide linkages. EGF is also present in biological fluids such as plasma, saliva, milk, urine, amniotic fluid, sweat, pancreatic juice, and cerebrospinal fluid [3–5]. EGF exhibits diverse biological actions, influencing proliferation, differentiation, and functional activities of various types of mammalian cells [3–6]. EGF has also been a useful tool for the analysis of receptor hormone interactions and receptor mediated endocytosis of polypeptide hormones. Several excellent reviews of the chemistry and biology of EGF have been published [3–7].
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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ScienceEpidermal Growth Factors Enhances Viral Transformation of Granulosa Cells
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