6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behavior in rats
Brain ResearchPublished 1 December 1974
Irving M. Asher, George K. Aghajanian
Citations117
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
The results indicate that amphetamine-induced stereotyped behavior is mediated by the dopamine projection to the head of the caudate nucleus of rats, and the mesolimbic dopamine pathways does not appear to be necessary for amphetamine -induced stereotypy.
Abstract
Amphetamine-induced stereotyped behavior in rats has been used as an animal model of psychosis. Much evidence has indicated that this behavior is mediated by an effect of amphetamine on CNS dopamine. There are two distinct ascending dopamine pathways (i.e. nigro-striatal and mesolimbic). Attempts to determine which of these two pathways mediates amphetamine-induced stereotypy have been inconclusive. In an effort to clarify this question 6-hydroxydopamine lesions were made in the forebrain terminal areas of the two pathways in rats and the response of the animals to the subsequent administration ofd-amphetamine and apomorphine observed. The brains were then analyzed by histofluorescence microscopy to determine the boundaries of dopamine depleted areas. The results indicate that amphetamine-induced stereotyped behavior is mediated by the dopamine projection to the head of the caudate nucleus. The mesolimbic dopamine pathways does not appear to be necessary for amphetamine-induced stereotypy.
Keywords
NeuroscienceNursing
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