Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
NaturePublished 1 October 1990
Sen Li, E. Bryan Crenshaw, Elizabeth J. Rawson, Donna M. Simmons, Larry W. Swanson, Michael G. Rosenfeld
Citations1,215
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.
Abstract
Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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