Immunological dissection of human Ia molecules.
The Journal of Experimental MedicinePublished 1 December 1978Open access
Roberto Tosi, Nobutaka Tanigaki, D. Centis, Giovanni Battista Ferrara, David Pressman
Citations263
SJR quartileQ1
SJR score5.83
SNIP1.99
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TL;DR
Evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus, and the alloantigenic determinants appear to be expressed on the small Ia subunit.
Abstract
The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
Keywords
Immunology and Microbiology
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